Spots Global Cancer Trial Database for Recurrence of Liver Malignancy After Ischemia/Reperfusion Injury

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Trial Identification

Brief Title: Recurrence of Liver Malignancy After Ischemia/Reperfusion Injury

Official Title: Does Vascular Occlusion in Liver Resections Predispose to Recurrence of Malignancy in the Liver Remnant Due to Ischemia/Reperfusion Injury?

Study ID: NCT04257240

Conditions

Ischemic Reperfusion Injury

Interventions

selective hepatic vascular exclusion

semielective hepatic vascular exclusion

Study Description

Brief Summary: Severe ischemic changes of the liver remnant after hepatectomy could expedite tumor recurrence on the residual liver. Our study aimed at assessing the effect of warm ischemic/reperfusion (I/R) injuries on surgery-to-local recurrence interval and patient overall survival, during major hepatectomies under inflow and outflow vascular control.

Detailed Description: One hundred and eighteen patients were subjected to liver resection under total inflow and outflow vascular clamping and were assigned as study group. These individuals were retrospectively matched to 112 counterparts, who underwent liver surgery applying inflow and outflow vascular clamping only of the segment harboring the tumor, sparing the liver remnant from any I/R injury (control group). The two cohorts were compared regarding recurrence-free survival and overall survival.