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Liver Extracts

patients subjected to major hepatectomy with vascular control of blood inflow and outflow of the whole liver

patients subjected to major hepatectomy by selectively clamping the portal and hepatic vessels only of the lobe harboring the tumor

major hepatectomy with vascular control of blood inflow and outflow of the whole liver

selective hepatic vascular exclusion

major liver resection by selectively clamping the portal and hepatic vessels only of the lobe harboring the tumor

semielective hepatic vascular exclusion

Kassiani Theodoraki, PhD

Severe ischemic changes of the liver remnant after hepatectomy could expedite tumor recurrence on the residual liver. Our study aimed at assessing the effect of warm ischemic/reperfusion (I/R) injuries on surgery-to-local recurrence interval and patient overall survival, during major hepatectomies under inflow and outflow vascular control.

One hundred and eighteen patients were subjected to liver resection under total inflow and outflow vascular clamping and were assigned as study group. These individuals were retrospectively matched to 112 counterparts, who underwent liver surgery applying inflow and outflow vascular clamping only of the segment harboring the tumor, sparing the liver remnant from any I/R injury (control group). The two cohorts were compared regarding recurrence-free survival and overall survival.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Recurrence of Liver Malignancy After Ischemia/Reperfusion Injury	NCT04257240	Ischemic Reperf... Liver Injury Cancer Recurren... Malignancy Liver Cancer	selective hepat... semielective he...	18 Years - 90 Years	Aretaieion University Hospital
Recurrence of Liver Malignancy After Ischemia/Reperfusion Injury	NCT04257240	Ischemic Reperf... Liver Injury Cancer Recurren... Malignancy Liver Cancer	selective hepat... semielective he...	18 Years - 90 Years	Aretaieion University Hospital

Spots Global Cancer Trial Database for semielective hepatic vascular exclusion