Spots Global Cancer Trial Database for Study of Avutometinib (VS-6766) +Defactinib With Gemcitabine and Nab-paclitaxel in Patients With Pancreatic Cancer
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Trial Identification
Brief Title: Study of Avutometinib (VS-6766) +Defactinib With Gemcitabine and Nab-paclitaxel in Patients With Pancreatic Cancer
Official Title: A Phase 1b/2a Study of Gemcitabine and Nab-paclitaxel in Combination With Avutometinib (VS-6766) and Defactinib in Patients With Previously Untreated Metastatic Adenocarcinoma of the Pancreas
Study ID: NCT05669482
Study Description
Brief Summary: This study will assess the safety and efficacy of avutometinib (VS-6766) and defactinib in combination with gemcitabine and nab-paclitaxel in patients with Pancreatic Ductal Adenocarcinoma (PDAC) who have been previously untreated.
Detailed Description: This is a multicenter, non-randomized, open-label Phase 1/2 study designed to evaluate safety, tolerability and efficacy of avutometinib (VS-6766) and defactinib in combination with gemcitabine and nab-paclitaxel in patients previously untreated metastatic Pancreatic Ductal Adenocarcinoma (PDAC).
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States
University of Chicago, Chicago, Illinois, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
Washington University School of Medicine, Saint Louis, Missouri, United States
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health, New York, New York, United States
New York Presbyterian/Weill-Cornell Medical Center, New York, New York, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
University of Pennsylvania, Philadelphia, Pennsylvania, United States
University of Utah Huntsman Cancer Institute, Salt Lake City, Utah, United States
Virginia Mason Medical Center, Seattle, Washington, United States
Fred Hutchinson Cancer Center, Seattle, Washington, United States
Contact Details
Name: MD Verastem
Affiliation: Verastem, Inc.
Role: STUDY_DIRECTOR
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