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Spots Global Cancer Trial Database for Acalabrutinib in Combination With R-miniCHOP in Older Adults With Untreated Diffuse Large B-Cell Lymphoma

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Trial Identification

Brief Title: Acalabrutinib in Combination With R-miniCHOP in Older Adults With Untreated Diffuse Large B-Cell Lymphoma

Official Title: A Randomized, Open-label, Phase 3 Study of Acalabrutinib in Combination With Rituximab and Reduced Dose CHOP (R-miniCHOP) in OldEr Adults With Untreated Diffuse Large B-Cell Lymphoma

Study ID: NCT05820841

Study Description

Brief Summary: The goal of this clinical trial is to study the addition of Acalabrutinib to standard R-miniCHOP in older adults with DLBCL. The main question it aims to answer is whether progression free survival kann be prolonged with the addition of Acalabrutinib. Participants will be randomised to receive either R-miniCHOP alone or R-miniCHOP with Acalabrutinib.

Detailed Description:

Eligibility

Minimum Age: 61 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Saarland University Medical Center, Homburg, Saarland, Germany

MVZ am Klinikum Aschaffenburg, Aschaffenburg, , Germany

Helios Klinikum Emil von Behring, Berlin, , Germany

Onkologische Schwerpunktpraxis Kurfürstendamm, Berlin, , Germany

Gemeinschaftspraxis Mohm/Prange-Krex, Dresden, , Germany

Universitätsklinikum Gießen und Marburg, Standort Gießen, Gießen, , Germany

Universitätsmedizin Greifswald, Greifswald, , Germany

Universitätsmedizin Halle (Saale), Halle, , Germany

Städtisches Klinikum Karlsruhe, Karlsruhe, , Germany

Johannes Wesling Klinikum, Minden, , Germany

Rheinland Klinikum-Lukaskrankenhaus Neuss, Neuss, , Germany

Brüderkrankenhaus St. Josef, Paderborn, , Germany

CaritasKlinikum Saarbrücken St. Theresia, Saarbrücken, , Germany

Klinikum Mutterhaus der Borromäerinnen, Trier, , Germany

Krankenhaus der Barmherzigen Brüder Trier, Trier, , Germany

Bundeswehrkrankenhaus Ulm, Ulm, , Germany

Universitätsklinikum Ulm, Ulm, , Germany

Contact Details

Name: Konstantinos Christofyllakis, MD MSc

Affiliation: Saarland University Medical Center

Role: PRINCIPAL_INVESTIGATOR

Name: Moritz Bewarder, MD, PD

Affiliation: Saarland University Medical Center

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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