Spots Global Cancer Trial Database for Biomarkers in Tissue Samples From Young Patients With Acute Myeloid Leukemia

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Trial Identification

Brief Title: Biomarkers in Tissue Samples From Young Patients With Acute Myeloid Leukemia

Official Title: Promoter Methylation in MLL-Rearranged Childhood AML

Study ID: NCT01229956

Conditions

Leukemia

Interventions

DNA methylation analysis

gene expression analysis

microarray analysis

reverse transcriptase-polymerase chain reaction

laboratory biomarker analysis

Study Description

Brief Summary: RATIONALE: Studying samples of tissue from patients with cancer the in laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research study is studying biomarkers in tissue samples from young patients with acute myeloid leukemia.

Detailed Description: OBJECTIVES: * To determine whether the pattern of global and TSG-specific promoter CpG island hypermethylation and gene silencing that we have shown characterizes MLL-rearranged (MLL-r) infant bilineage ALL is also characteristic of other subsets of MLL-r leukemia. OUTLINE: Previously collected cryopreserved cells from diagnosis are analyzed for promoter methylation via HELP arrays, gene expression arrays, and RT-qPCR. PROJECTED ACCRUAL: A total of 32 samples (8 from each of 4 biologically defined cohorts) will be analyzed.