Spots Global Cancer Trial Database for Biomarkers in Patients at Risk of Developing Myelodysplastic Syndrome or Other Disorders and in Healthy Participants

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Trial Identification

Brief Title: Biomarkers in Patients at Risk of Developing Myelodysplastic Syndrome or Other Disorders and in Healthy Participants

Official Title: Molecular and Functional Characterisation of Bone Marrow Function in Normal Subjects, Myelodysplastic Syndromes (MDS) and Secondary Disorders of Heamatopoiesis

Study ID: NCT00899327

Conditions

Leukemia

Myelodysplastic Syndromes

Interventions

DNA methylation analysis

RNA analysis

cytogenetic analysis

gene expression analysis

mutation analysis

polymerase chain reaction

protein expression analysis

laboratory biomarker analysis

Study Description

Brief Summary: RATIONALE: Studying samples of blood and bone marrow in the laboratory from patients at risk of developing myelodysplastic syndrome may help doctors learn more about changes that occur in DNA and identify biomarkers related to disorders of the blood and bone marrow. PURPOSE: This research study is looking at biomarkers in patients at risk of developing myelodysplastic syndrome or other disorders and in healthy participants.

Detailed Description: OBJECTIVES: Primary * To identify novel biomarkers of disease that would help in the initial diagnosis of myelodysplastic syndromes (MDS). Secondary * To understand the genesis of anemia in cancers. * To identify novel biomarkers of disease that predict progression of MDS to acute myeloid leukemia. OUTLINE: Blood and bone marrow samples are collected. Hemopoietic stem cells (HSC) and progenitor cells are isolated from samples for analysis. Some of these HSC and progenitor cells are used for functional assays. From the rest of the cells, DNA, RNA, and protein is extracted for molecular analyses, including gene mutation analysis, gene methylation assays, chromatin immunoprecipitation, microarray, and real-time polymerase chain reaction.