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Brief Title: A Clinical Trial to Evaluate Safety and Efficacy of Endovascualr Denervation in Treatment of Cancer Pain
Official Title: A Prospective, Multicenter, Self-Control Clinical Trial to Evaluate Safety and Efficacy of Endovascular Denervation in Treatment of Cancer Pain
Study ID: NCT04014478
Brief Summary: A prospective, multicenter, self-control clinical trial aim to enroll 110 patients suffered from upper abdominal (liver, pancreas, stomach, etc.) cancers . Patients who have taken at least one opioid drug for pain for two weeks and still have a VAS pain scale greater than 6 will receive endovascular denervation (EDN). They will be followed up for 3 months. The VAS scales, quantity of analgesics as represented by morphine equivalent and quality of life scores will be compared before and after EDN. Safety parameters such as arterial deformation, embolism, infection, liver and kidney functions will also be monitored.
Detailed Description:
Minimum Age: 25 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Name: Gao-Jun Teng, MD
Affiliation: Zhongda Hospital
Role: STUDY_CHAIR
Name: zhong-Min Wang, MD
Affiliation: Shanghai JiaoTong University Affiliated RuiJin Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Jian Wang, MD
Affiliation: Beijing University Affiliated the First Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Wen-Tao Li, MD
Affiliation: Fudan University Affiliated Cancer Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Chuan-Sheng Zheng, MD
Affiliation: HuaZhong University of Science and Technology Affiliated Union Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Wei-Fu Lv, MD
Affiliation: China University of Science and Technology Affiliated the First Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Jun-Hui Sun, MD
Affiliation: Zhejiang University Affiliated the First Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Hao Xu, MD
Affiliation: XuZhou Medical College Affiliated Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Ming Huang, MD
Affiliation: Yunnan Cancer Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Li-Gong Lu, MD
Affiliation: The People's Hospital of Zhuhai City
Role: PRINCIPAL_INVESTIGATOR
Name: Jian-Song Ji, MD
Affiliation: The Central Hospital of Lishui City
Role: PRINCIPAL_INVESTIGATOR