Neoplasms

All Conditions

Digestive System Diseases

Gland and Hormone Related Diseases

Symptoms and General Pathology

Nervous System Diseases

Rare Diseases

Cholangiocarcinoma

Pancreatic Neoplasms

Stomach Neoplasms

Cancer Pain

Liver Neoplasms

Pain

Bile Duct Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Neurologic Manifestations

Endocrine Gland Neoplasms

Pancreatic Diseases

Endocrine System Diseases

Biliary Tract Neoplasms

Bile Duct Diseases

Biliary Tract Diseases

Adenocarcinoma

Carcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Stomach Diseases

Pancreatic Cancer

Bile Duct Cancer

Stomach Cancer

A radiofrequency ablation catheter will be placed in abdominal aorta. At least 6 sites will be ablated with settings of temerature at 60 degree centigrade and time at 120 seconds.

Endovascular Denervation

Hua Qing Yin, PhD

Gao-Jun Teng, MD

zhong-Min Wang, MD

Jian Wang, MD

Wen-Tao Li, MD

Chuan-Sheng Zheng, MD

Wei-Fu Lv, MD

Jun-Hui Sun, MD

Hao Xu, MD

Ming Huang, MD

Li-Gong Lu, MD

Jian-Song Ji, MD

A prospective, multicenter, self-control clinical trial aim to enroll 110 patients suffered from upper abdominal (liver, pancreas, stomach, etc.) cancers . Patients who have taken at least one opioid drug for pain for two weeks and still have a VAS pain scale greater than 6 will receive endovascular denervation (EDN). They will be followed up for 3 months. The VAS scales, quantity of analgesics as represented by morphine equivalent and quality of life scores will be compared before and after EDN. Safety parameters such as arterial deformation, embolism, infection, liver and kidney functions will also be monitored.

A Clinical Trial to Evaluate Safety and Efficacy of Endovascualr Denervation in Treatment of Cancer Pain

A Prospective, Multicenter, Self-Control Clinical Trial to Evaluate Safety and Efficacy of Endovascular Denervation in Treatment of Cancer Pain

Pain scale is evaluated as Woodforde Visual Analig Scale (VAS) method. The scale is from 0 to 10, with 0 being no pain, and 10 being unbearable pain.

All analgesics used will be calculated to Morphine Equivalent using published conversion factors.

Qulaity of Life Scores are obtained using Functional Assessment of Cancer Theray-Generic Scale (FACT-G) (v 4.0) sale. The score is from 0 to 108, with 0 being no quality of life, and 108 being highest quality of life.

Shanghai Golden Leaf MedTec Co. Ltd

multi-electrode catheter-based endovascular denervation

endovascular denervation

Qi Zhang, PhD

Endovascular arterial denervation (ED) is a minimally invasive technique which could reduce the occurrence of injury of visceral tissue or organs. As the principle of renal denervation (RDN), Radiofrequency energy delivered by a multi-electrode catheter to the celiac plexus over the anterolateral surface of the superior mesenteric artery (SMA) and the celiac axis. Damaged or partially damaged celiac plexus can achieve the effect of pain relief.

The multi-electrode catheter was consisted of six independent electrodes helically on a net structure, which could be set as the same energy and temperature for simultaneous multi-point ablation. A real-time monitoring capability also provided by the display.

Endovascular Denervation in Patients With Cancer Pain

Changes of the visual analogue scores (VAS) scores

Changes of the 100-item World Health Organization Quality of Life (QOL)

Assess artery damage, such as abdominal aortic dissection and abdominal aneurysm, by digital subtraction angiography or computed tomography

Zhongda Hospital

Dean

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
A Clinical Trial to Evaluate Safety and Efficacy of Endovascualr Denervation in Treatment of Cancer Pain	NCT04014478	Liver Cancer Pancreas Cancer Stomach Cancer Bile Duct Cance...	Endovascular De...	25 Years - 75 Years	Shanghai Golden Leaf MedTec Co. Ltd
Endovascular Denervation in Patients With Cancer Pain	NCT03431922	Cancer Pain	endovascular de...	25 Years - 75 Years	Zhongda Hospital
Endovascular Denervation in Patients With Cancer Pain	NCT03431922	Cancer Pain	endovascular de...	25 Years - 75 Years	Zhongda Hospital
Endovascular Denervation in Patients With Cancer Pain	NCT03431922	Cancer Pain	endovascular de...	25 Years - 75 Years	Zhongda Hospital

Spots Global Cancer Trial Database for endovascular denervation