Spots Global Cancer Trial Database for Biomarkers in Predicting Response to Chemotherapy in Samples From Young Patients With Osteosarcoma

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Trial Identification

Brief Title: Biomarkers in Predicting Response to Chemotherapy in Samples From Young Patients With Osteosarcoma

Official Title: Observational - Methylation Status as Predictor of Response to Neoadjuvant Chemotherapy in Osteosarcoma

Study ID: NCT01374672

Conditions

Localized Osteosarcoma

Metastatic Osteosarcoma

Osteoblastic Osteosarcoma

Recurrent Osteosarcoma

Interventions

laboratory biomarker analysis

Study Description

Brief Summary: This research study is studying biomarkers in predicting response to chemotherapy in samples from young patients with osteosarcoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.

Detailed Description: Study Subtype: Ancillary/Correlative Observational Study Model: Cohort Time Perspective: Retrospective Biospecimen Retention: Samples With DNA Biospecimen Description: Tissue Study Population Description: Children's Oncology Group Sampling Method: Non-Probability Sample PRIMARY OBJECTIVES: I. Determine whether methylation status predicts response to neoadjuvant chemotherapy in samples from children and young adults with osteosarcoma. OUTLINE: Patients are stratified according to response to neoadjuvant chemotherapy (good vs poor). DNA and RNA extracted from biopsy samples are analyzed for methylation changes and transcription changes by ligation-mediated PCR and mass-array genotyping.