Spots Global Cancer Trial Database for Study of Blood Samples From Patients With Osteosarcoma
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Trial Identification
Brief Title: Study of Blood Samples From Patients With Osteosarcoma
Official Title: Retrospective Study of Genetic Risk Factors for Osteosarcoma
Study ID: NCT00954473
Interventions
Study Description
Brief Summary: This research trial studies blood samples from patients with osteosarcoma. Studying the genes found in samples of blood from patients with osteosarcoma may help doctors identify biomarkers related to the disease.
Detailed Description: PRIMARY OBJECTIVE: I. Conduct a large-scale candidate gene association study in osteosarcoma (OS) using cases from the national Children's Oncology Group (COG) OS biology study (P9851 and successor study AOST06B1). SECONDARY OBJECTIVES: I. Conduct a genome-wide association study (GWAS) of OS. II. Fine-map genomic regions associated with OS to identify putative functional loci. III. Conduct whole-exome sequencing of germline OS deoxyribonucleic acid (DNA) samples. IV. Investigate the functional implications of promising genetic variants associated with OS. OUTLINE: Blood samples undergo polymorphism analysis of common single-nucleotide polymorphisms and haplotypes to examine genetic variation, gene-gene interactions, and the population structure.
Keywords
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Children's Oncology Group, Arcadia, California, United States
Contact Details
Name: Sharon Savage, MD
Affiliation: Children's Oncology Group
Role: PRINCIPAL_INVESTIGATOR
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