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Brief Title: A Clinical Study Conducted in Multiple Centers Evaluating Escalating Doses of Veliparib in Combination With Capecitabine and Radiation in Patients With Locally Advanced Rectal Cancer
Official Title: An Open-Label Phase 1b Study of the Safety and Tolerability of Veliparib in Combination With Capecitabine and Radiation in Subjects With Locally Advanced Rectal Cancer (LARC)
Study ID: NCT01589419
Brief Summary: An open-label, Phase 1b, dose escalation study evaluating the safety and tolerability of the PARP inhibitor Veliparib in combination with capecitabine and radiation in subjects with locally advanced rectal cancer (LARC).
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Site Reference ID/Investigator# 99095, Scottsdale, Arizona, United States
Site Reference ID/Investigator# 68044, Chicago, Illinois, United States
Site Reference ID/Investigator# 112395, Goshen, Indiana, United States
Site Reference ID/Investigator# 68045, Durham, North Carolina, United States
Site Reference ID/Investigator# 68043, Madison, Wisconsin, United States
Site Reference ID/Investigator# 67882, East Melbourne, , Australia
Name: Philip Komarnitsky, MD
Affiliation: AbbVie
Role: STUDY_DIRECTOR