Spots Global Cancer Trial Database for locally advanced rectal cancer

Every month we try and update this database with for locally advanced rectal cancer cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Induction Chemotherapy for Locally Advanced Rectal Cancer	NCT04838496	Rectal Cancer	FOLFOXIRI Proto...	18 Years -	Catharina Ziekenhuis Eindhoven
Preoperative Radiochemotherapy With Hyperthermia for Locally Advanced Rectal Cancer	NCT02353858	Rectal Cancer Locally Advance... Hyperthermia Hyperthermic Ra... Hyperthermic Ch... Deep Regional H...	Deep regional h... Radiotherapy Chemotherapy (5...	18 Years - 80 Years	University Hospital Tuebingen
Short-course Radiotherapy Based TNT Combined With PD-1 Inhibitor for Locally Advanced Rectal Cancer	NCT04518280	Locally Advance...	PD-1 antibody Capecitabine Oxaliplatin Short-course ra...	18 Years - 70 Years	Fudan University
THeragnostic Utilities for Neoplastic DisEases of the Rectum by MRI Guided Radiotherapy	NCT04815694	Neoadjuvant Che... Locally Advance... Pathological Co...	RT Dose escalat...	18 Years -	Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Total Neoadjuvant Therapy of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer (ENSEMBLE)	NCT05646511	Locally Advance...	SCRT CAPOX CAPOXIRI	18 Years -	National Cancer Center Hospital East
Gut Microbiome and Its Immune Modulation in Locally Advanced Rectal Cancer	NCT05079503	Locally Advance...	GEN-001	19 Years -	Korean Cancer Study Group
Dendrobium Huoshanense Suppository in Rectal Cancer	NCT05079438	Locally Advance...	Dendrobium Huos...	18 Years - 75 Years	Zhejiang Cancer Hospital
Node-sparing Radiotherapy Combined With Total Neoadjuvant CAPOX and Sintilimab for MSS Middle and Low Rectal Cancer	NCT06204094	Locally Advance...	node-sparing sh... Sintilimab Capecitabine Oxaliplatin TME surgery watch and wait	18 Years - 75 Years	Jinhua Central Hospital
Neoadjuvant Bevacizumab, Capecitabine and Radiation Therapy With or Without Oxaliplatin Locally Advanced Rectal Cancer	NCT00828672	Locally Advance...	Oxaliplatin Bevacizumab Capecitabine radiotherapy	18 Years -	Universitaire Ziekenhuizen KU Leuven
Evaluation of Efficacy, Quality of Life and Cost Effectiveness of Short-course Radiotherapy Followed by Capecitabine Plus Oxaliplatin chemotheRapy and TME for High-risk Rectal Cancer (ESCORT Trial)	NCT03676517	Locally Advance...	preoperative sh...	19 Years - 80 Years	Yonsei University
Chemoradiation With Enadenotucirev as a Radiosensitiser in Locally Advanced Rectal Cancer	NCT03916510	Locally Advance...	Enadenotucirev Capecitabine Radiotherapy	18 Years -	University of Oxford
A Contemporary Review of Surgical Approaches in Pelvic Exenterative Surgery	NCT04948762	Pelvic Exentera... Advanced Pelvic... Locally Advance...		18 Years -	St Vincent's University Hospital, Ireland
Dose-escalation Trial of Preoperative Radiotherapy and Concurrent Chemotherapy in Locally Advanced Rectal Cancer	NCT02964468	Locally Advance...	3DCRT treatment... Dose Escalation...	18 Years - 90 Years	Grupo de Investigación Clínica en Oncología Radioterapia
Dose-escalation Trial of Preoperative Radiotherapy and Concurrent Chemotherapy in Locally Advanced Rectal Cancer	NCT02964468	Locally Advance...	3DCRT treatment... Dose Escalation...	18 Years - 90 Years	Grupo de Investigación Clínica en Oncología Radioterapia
Consolidation Versus Induction Chemotherapy in Total Neoadjuvant Therapy of Rectal Cancer With High Risk for Recurrence	NCT05054959	Locally Advance...	consolidation c... induction chemo...	18 Years -	Institute of Oncology Ljubljana
Short-course Radiotherapy Based TNT Combined With PD-1 Inhibitor for Locally Advanced Rectal Cancer	NCT04518280	Locally Advance...	PD-1 antibody Capecitabine Oxaliplatin Short-course ra...	18 Years - 70 Years	Fudan University
SCRT Sequential Penpulimab in Combination With CAPEOX in the Neoadjuvant Treatment of MSS Locally Advanced Rectal Cancer	NCT05576480	Rectal Cancer Locally Advance...	Short-course ra... Penpulimab CAPEOX TME surgery	18 Years - 75 Years	Ruijin Hospital
Organ Preservation in Locally Advanced Rectal Cancer	NCT03064646	LOCALLY ADVANCE...	Organ Preservat...	18 Years -	Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Combination of AK104 and Neoadjuvant Chemoradiotherapy in pMMR/MSS Locally Advanced Rectal Cancer	NCT05980689	Locally Advance...	AK104 Capecitabine Neoadjuvant Rad...	18 Years - 75 Years	Sun Yat-sen University
Preoperative Radiotherapy With Capecitabine and Bevacizumab in Locally Advanced Rectal Cancer: CRAB Phase II Study	NCT00842686	Locally Advance...	bevacizumab, ca...	18 Years - 80 Years	Institute of Oncology Ljubljana
Dose-escalation Trial of Preoperative Radiotherapy and Concurrent Chemotherapy in Locally Advanced Rectal Cancer	NCT02964468	Locally Advance...	3DCRT treatment... Dose Escalation...	18 Years - 90 Years	Grupo de Investigación Clínica en Oncología Radioterapia
Nimotuzumab in Combination With Chemoradiation in Patients With Locally Advanced Rectal Cancer	NCT01899118	Locally Advance...	Preoperative ir... Nimotuzumab Oxaliplatin Capecitabine	18 Years - 75 Years	Zhejiang Cancer Hospital
Exercise for Improving Radiotherapy Efficacy in Rectal Cancer	NCT06292975	Locally Advance...	Supervised Vigo...	18 Years -	University of Hull
Preoperative Combined Induction Chemotherapy With Capecitabine, Oxaliplatin, Bevacizumab and Radiotherapy	NCT01434147	Rectal Cancer	preoperative in...	18 Years - 80 Years	Austrian Breast & Colorectal Cancer Study Group
A Clinical Study Conducted in Multiple Centers Evaluating Escalating Doses of Veliparib in Combination With Capecitabine and Radiation in Patients With Locally Advanced Rectal Cancer	NCT01589419	Locally Advance...	veliparib capecitabine radiation	18 Years - 99 Years	AbbVie
UGT1A1 Combined With Pharmacokinetics of SN-38 in CPT-11-based CRT in Patients With Advanced Rectal Cancer	NCT03824899	Locally Advance...	Blood concentra...	18 Years - 75 Years	Fudan University
Short-course Preoperative Chemoradiotherapy for Rectal Cancer	NCT01431599	Rectal Cancer	short-course ra...	18 Years - 75 Years	Seoul St. Mary's Hospital
Carbon Nanoparticles as Lymph Node Tracer in Rectal Cancer After Neoadjuvant Radiochemotherapy	NCT03550001	Rectal Cancer	Injection CNP b...	18 Years - 75 Years	Peking University People's Hospital
Endoscopic Assisted Electrochemotherapy in Addition to Neoadjuvant Treatment of Locally Advanced Rectal Cancer	NCT03040180	Locally Advance... Electrochemothe... Neoadjuvant The... Down Staging	Electrochemothe... EndoVE	18 Years -	Zealand University Hospital
Total Neoadjuvant Treatment Plus PD-1 in Mid-Low Locally Advanced Rectal Cancer	NCT04906044	Tislelizumab Locally Advance... Total Neoadjuva... PD-1	Sintilimab	18 Years - 80 Years	The First Hospital of Jilin University
Dendrobium Huoshanense Suppository in Rectal Cancer	NCT05079438	Locally Advance...	Dendrobium Huos...	18 Years - 75 Years	Zhejiang Cancer Hospital
Minimal Invasive Strategies for Good and Complete Response to Chemoradiation in Rectal Cancer	NCT00939666	Locally Advance...	Wait&see or TEM...	18 Years -	Maastricht University Medical Center
Intraoperative Electron Radiotherapy in Rectal Cancer - A Feasibility Trial	NCT05877352	Locally Advance... Locally Recurre...	Intraoperative ... Extended Margin...	16 Years -	University Hospital Southampton NHS Foundation Trust
Short-course Radiotherapy Followed by Consolidation Chemotherapy. 2021-001206-29	NCT05253846	Locally Advance...	Irinotecan Oxaliplatin Lederfolin 5-Fluorouracil Short-course ra... TME	18 Years - 70 Years	Gruppo Oncologico del Nord-Ovest
Carbon Nanoparticles as Lymph Node Tracer in Rectal Cancer After Neoadjuvant Radiochemotherapy	NCT03550001	Rectal Cancer	Injection CNP b...	18 Years - 75 Years	Peking University People's Hospital
RadioPathomics Artificial Intelligence Model to Predict Tumor Regression Grading in Locally Advanced Rectal Cancer	NCT04273451	Rectal Cancer		18 Years - 75 Years	Sixth Affiliated Hospital, Sun Yat-sen University
Nelfinavir, a Phase I/Phase II Rectal Cancer Study	NCT00704600	Colorectal Canc... Colorectal Carc... Colorectal Tumo... Neoplasms, Colo...	nelfinavir	18 Years -	Maastricht Radiation Oncology
Pre-operative 3-DCRT vs IMRT for Locally Advanced Rectal Cancer	NCT02151019	Locally Advance...	IMRT	18 Years -	Cancer Trials Ireland
Neoadjuvant Treatment With Regorafenib and Capecitabine Combined With Radiotherapy in Locally Advanced Rectal Cancer	NCT02910843	Rectal Cancer	Regorafenib Capecitabine Radiotherapy Surgery	18 Years - 75 Years	Swiss Group for Clinical Cancer Research
Efficacy of NeoThermo-Radio-chemotherapy for LA Rectal Cancer Before Laparoscopic TME: Prospective Phase II Trial	NCT02290574	Locally Advance...	Hyperthermia wi...	20 Years -	Samsung Medical Center
Short-course Radiotherapy Followed by Consolidation Chemotherapy. 2021-001206-29	NCT05253846	Locally Advance...	Irinotecan Oxaliplatin Lederfolin 5-Fluorouracil Short-course ra... TME	18 Years - 70 Years	Gruppo Oncologico del Nord-Ovest
UGT1A1-Based Irinotecan Therapy for Locally Advanced Rectal Cancer	NCT05148767	Rectal Cancer S...	Neoadjuvant che...	18 Years - 75 Years	Zhejiang Cancer Hospital
Capecitabine, Irinotecan Hydrochloride, Cetuximab, and Radiation Therapy in Treating Patients Undergoing Surgery for Locally Advanced Rectal Cancer	NCT00972881	Rectal Cancer	cetuximab capecitabine irinotecan hydr... neoadjuvant the... therapeutic con... radiation thera...	18 Years - 120 Years	University College, London
Inflammation After Laparoscopic Robot-assisted Surgery for Locally Advanced Rectal Cancer	NCT04324567	Locally Advance... Abdominoperinea...		18 Years - 100 Years	Oslo University Hospital
Assess the Efficacy of Radiotherapy and Sequential Chemotherapy and AK104 Before TME Surgery for Local CRC（AK104-IIT-13）	NCT05794750	Locally Advance...	AK104 injection TME surgery Capecitabine Oxaliplatin	18 Years - 75 Years	Cancer Institute and Hospital, Chinese Academy of Medical Sciences
An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer	NCT05914766	Rectal Cancer Self Efficacy	PATHWAYS Enhanced usual ...	18 Years -	Massachusetts General Hospital
UGT1A1-Based Irinotecan Therapy for Locally Advanced Rectal Cancer	NCT05148767	Rectal Cancer S...	Neoadjuvant che...	18 Years - 75 Years	Zhejiang Cancer Hospital
Short-course Preoperative Chemoradiotherapy for Rectal Cancer	NCT01431599	Rectal Cancer	short-course ra...	18 Years - 75 Years	Seoul St. Mary's Hospital
CAPOX and PD-1 Antibody Combined With or Without Radiotherapy for MSS Locally Advanced Rectal Cancer	NCT06281405	Locally Advance... Neoadjuvant The...	PD-1 antibody Capecitabine Short-course ra...	18 Years - 70 Years	Fudan University
Study of Peposertib in Combination With Capecitabine and RT in Rectal Cancer	NCT03770689	Locally Advance...	Peposertib 50 m... Peposertib 100 ... Peposertib 150 ... Peposertib 250 ... Capecitabine Radiotherapy (R...	18 Years -	EMD Serono
Constructing a Multimodal Imaging System to Predict the Risk of Heterochronous Metastasis of Rectal Cancer	NCT06293612	Locally Advance... Distant Metasta...	No intervention...	-	Cancer Institute and Hospital, Chinese Academy of Medical Sciences
SCRT in TNT With or Without Chlorophyllin	NCT05856305	Rectal Neoplasm...	Chlorophyllin, ... Placebo	18 Years - 90 Years	Tata Memorial Centre
Neoadjuvant Triplet Chemotherapy Regimen in Patients With Locally Advanced Rectal Cancer	NCT03443661	Locally Advance...	FOLFOXIRI	18 Years - 70 Years	ChineseAMS
Selinexor Combined With Standard Chemoradiation as Neoadjuvant Treatment in Locally Advanced Rectal Cancer	NCT02137356	Rectal Neoplasm...	standard dose p... standard dose c... dose-escalated ...	18 Years -	Sheba Medical Center
Radiation-protection Effect of Amifostine in Locally Advanced Rectal Cancer	NCT03702985	Locally Advance...	Radiation Capecitabine Irinotecan Amifostine	18 Years - 75 Years	Fudan University
Short-course Radiotherapy Followed by Fruquintinib Plus Adebrelimab and CAPOX in the Full Course Neoadjuvant Treatment of Locally Advanced Rectal Cancer: a Multicenter, Single-arm, Open-label Study	NCT06234007	Locally Advance...	Fruquintinib, A...	18 Years - 75 Years	Wuhan Union Hospital, China
Benchmarking Trial Between France and Australia Comparing Management of Primary Rectal Cancer Beyond TME (Total Mesorectum Excision) and Locally Recurrent Rectal Cancer	NCT02551471	Rectal Cancer	Blinded inter-c... MDT (Multidisci... Semi-structured...	18 Years -	University Hospital, Bordeaux
Preoperative Radiochemotherapy With Hyperthermia for Locally Advanced Rectal Cancer	NCT02353858	Rectal Cancer Locally Advance... Hyperthermia Hyperthermic Ra... Hyperthermic Ch... Deep Regional H...	Deep regional h... Radiotherapy Chemotherapy (5...	18 Years - 80 Years	University Hospital Tuebingen
Pre-operative 3-DCRT vs IMRT for Locally Advanced Rectal Cancer	NCT02151019	Locally Advance...	IMRT	18 Years -	Cancer Trials Ireland
Induction Chemotherapy,Radiochemotherapy, Consolidation Chemotherapy in Preoperative Treatment of Rectal Cancer	NCT01489332	Rectal Cancer	intensified pre...	18 Years -	Institute of Oncology Ljubljana
TIME in Immunotherapy Combined With nCRT for Rectal Cancer	NCT05507112	Locally Advance...	PD-1 inhibitor Capecitabine Long-course rad...	18 Years - 75 Years	Peking Union Medical College Hospital
Exercise for Improving Radiotherapy Efficacy in Rectal Cancer	NCT06292975	Locally Advance...	Supervised Vigo...	18 Years -	University of Hull
Neoadjuvant Bevacizumab, Capecitabine and Radiation Therapy With or Without Oxaliplatin Locally Advanced Rectal Cancer	NCT00828672	Locally Advance...	Oxaliplatin Bevacizumab Capecitabine radiotherapy	18 Years -	Universitaire Ziekenhuizen KU Leuven
The Effect of Cancer Therapies and Exercise on Mitochondrial Energetics and Fitness	NCT01859442	Locally Advance...	Structured resp... Sham group	18 Years -	Liverpool University Hospitals NHS Foundation Trust
Preoperative Radiotherapy With Capecitabine and Bevacizumab in Locally Advanced Rectal Cancer: CRAB Phase II Study	NCT00842686	Locally Advance...	bevacizumab, ca...	18 Years - 80 Years	Institute of Oncology Ljubljana
Dendrobium Huoshanense Suppository in Rectal Cancer	NCT05079438	Locally Advance...	Dendrobium Huos...	18 Years - 75 Years	Zhejiang Cancer Hospital
A Trial of High Intensity Versus Low Intensity Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer	NCT01064999	Rectal Cancer	Oxaliplatin Capecitabine Radiotherapy Surgery	18 Years - 75 Years	Fudan University
Detection and Inflammatory Characterization of Deep Infection After Surgery for Locally Advanced Rectal Cancer With Microdialysis Catheters	NCT03392584	Locally Advance... Abdominoperinea... Infection		18 Years -	Oslo University Hospital
Circulating Tumor DNA-guided Neoadjuvant Treatment Strategy for Locally Advanced Rectal Cancer	NCT05601505	Locally Advance... Circulating Tum...	circulating tum...	18 Years - 75 Years	Peking Union Medical College Hospital
RECTAL BOOST Study	NCT01951521	Rectal Cancer	Boost	18 Years -	UMC Utrecht
Capecitabine, Irinotecan Hydrochloride, Cetuximab, and Radiation Therapy in Treating Patients Undergoing Surgery for Locally Advanced Rectal Cancer	NCT00972881	Rectal Cancer	cetuximab capecitabine irinotecan hydr... neoadjuvant the... therapeutic con... radiation thera...	18 Years - 120 Years	University College, London
Induction Chemotherapy for Locally Advanced Rectal Cancer	NCT04838496	Rectal Cancer	FOLFOXIRI Proto...	18 Years -	Catharina Ziekenhuis Eindhoven
Assess the Efficacy of Radiotherapy and Sequential Chemotherapy and AK104 Before TME Surgery for Local CRC（AK104-IIT-13）	NCT05794750	Locally Advance...	AK104 injection TME surgery Capecitabine Oxaliplatin	18 Years - 75 Years	Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Trial of Capecitabine With or Without Irinotecan Driven by UGT1A1	NCT02605265	Locally Advance...	Radiation Capecitabine Irinotecan Oxaliplatin	18 Years - 75 Years	Fudan University
Neoadjuvant FOLFOXIRI Chemotherapy Alone for Locally Advanced Rectal Cancer	NCT02217020	Rectal Cancer	FOLFOXIRI	18 Years - 70 Years	Sun Yat-sen University
Efficacy of NeoThermo-Radio-chemotherapy for LA Rectal Cancer Before Laparoscopic TME: Prospective Phase II Trial	NCT02290574	Locally Advance...	Hyperthermia wi...	20 Years -	Samsung Medical Center
Neoadjuvant FOLFOXIRI Versus CapeOX Chemotherapy for Local Advanced Rectal Cancer	NCT05201430	Rectal Cancer	FOLFOXIRI CapeOX	18 Years - 75 Years	Fudan University
Response Assessment by Circulating Tumor DNA in Patients With Locally Advanced Rectal Cancer	NCT04670588	Rectal Cancer	Circulating tum...	18 Years -	Medical College of Wisconsin
The Effect of Cancer Therapies and Exercise on Mitochondrial Energetics and Fitness	NCT01859442	Locally Advance...	Structured resp... Sham group	18 Years -	Liverpool University Hospitals NHS Foundation Trust
The Combination of Immunotherapy and Neoadjuvant Chemoradiotherapy in MSS Locally Advanced Rectal Cancer	NCT04411537	Locally Advance...	PD-1 antibody Capecitabine Irinotecan Neoadjuvant Rad...	18 Years - 70 Years	Fudan University

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