Spots Global Cancer Trial Database for Brain Function in Children Previously Treated on Clinical Trials POG-9605 and POG-9201
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Trial Identification
Brief Title: Brain Function in Children Previously Treated on Clinical Trials POG-9605 and POG-9201
Official Title: Assessment of Clinical and Neuroradiologic Evidence of Methotrexate Leukoencephalopathy in Children Treated on POG 9605 and 9201
Study ID: NCT00028509
Interventions
Study Description
Brief Summary: RATIONALE: Assessing the effects of methotrexate on brain function in children may improve the ability to plan treatment and decrease side effects. PURPOSE: Clinical trial to compare brain function of children who have been previously treated with methotrexate.
Detailed Description: OBJECTIVES: * Compare the incidence of neuropsychological abnormalities and leukoencephalopathy in children previously treated with methotrexate on protocols POG-9605 versus POG-9201. OUTLINE: This is a multicenter study. More than 3 years after completion of therapy, patients undergo 9 different tests to assess intelligence, memory, learning, attention, concentration, processing of information, functioning, and visual-motor integration. Patients also undergo MRI of the head. PROJECTED ACCRUAL: A total of 30-54 patients previously treated on protocol POG-9201 will be accrued for this study. A total of 60-108 patients previously treated on protocol POG-9605 will be accrued for this study.
Eligibility
Minimum Age: 1 Year
Eligible Ages: CHILD
Sex: ALL
Healthy Volunteers: No
Locations
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
Stanford Comprehensive Cancer Center - Stanford, Stanford, California, United States
University of Miami Sylvester Comprehensive Cancer Center - Miami, Miami, Florida, United States
Miami Children's Hospital, Miami, Florida, United States
St. Joseph's Cancer Institute at St. Joseph's Hospital, Tampa, Florida, United States
Kaplan Cancer Center at St. Mary's Medical Center, West Palm Beach, Florida, United States
Cancer Research Center of Hawaii, Honolulu, Hawaii, United States
Rush University Medical Center, Chicago, Illinois, United States
CancerCare of Maine at Eastern Maine Medial Center, Bangor, Maine, United States
Floating Hospital for Children at Tufts - New England Medical Center, Boston, Massachusetts, United States
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States
Hurley Medical Center, Flint, Michigan, United States
Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods, Michigan, United States
University of Mississippi Cancer Clinic, Jackson, Mississippi, United States
Siteman Cancer Center at Barnes-Jewish Hospital, St. Louis, Missouri, United States
Hackensack University Medical Center Cancer Center, Hackensack, New Jersey, United States
University of New Mexico Cancer Research and Treatment Center, Albuquerque, New Mexico, United States
Roswell Park Cancer Institute, Buffalo, New York, United States
Blumenthal Cancer Center at Carolinas Medical Center, Charlotte, North Carolina, United States
Wake Forest University Comprehensive Cancer Center, Winston-Salem, North Carolina, United States
Oklahoma University Cancer Institute, Oklahoma City, Oklahoma, United States
Hollings Cancer Center at Medical University of South Carolina, Charleston, South Carolina, United States
Baylor University Medical Center - Houston, Houston, Texas, United States
University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States
Midwest Children's Cancer Center, Milwaukee, Wisconsin, United States
Montreal Children's Hospital at McGill University Health Center, Montreal, Quebec, Canada
Contact Details
Name: Patricia K. Duffner, MD
Affiliation: Women & Children's Hospital of Buffalo
Role: STUDY_CHAIR
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