Spots Global Cancer Trial Database for neurotoxicity
Every month we try and update this database with for neurotoxicity cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| A Pharmacokinetic and Pharmacodynamic Study of Vincristine in Children With Leukemia | NCT00001689 | Acute Lymphocyt... Leukemia | Vincristine | - | National Institutes of Health Clinical Center (CC) | |
| Relationship Between Platinum Levels in the Blood and Neurotoxicity in Patients Who Are Receiving Oxaliplatin for Gastrointestinal Cancer | NCT00274885 | Cancer | oxaliplatin management of t... | 18 Years - | National Cancer Institute (NCI) | |
| N-PhenoGENICS: Neurocognitive-Phenome, Genome, Epigenome and Nutriome In Childhood Leukemia Survivors | NCT01913093 | Childhood Leuke... | 8 Years - 20 Years | The Hospital for Sick Children | ||
| Study Evaluating Neurotoxicity in Patients With Metastatic Gastro Intestinal Cancer Taking Phycocare® or Placebo During Oxaliplatin Based Chemotherapy | NCT05025826 | Metastatic Gast... | Phycocare Placebo | 18 Years - | Nantes University Hospital | |
| Gabapentin in Treating Peripheral Neuropathy in Cancer Patients Undergoing Chemotherapy | NCT00027963 | Neurotoxicity Pain | gabapentin placebo | 18 Years - | Alliance for Clinical Trials in Oncology | |
| Acupuncture in Treating Nerve Pain in Patients With Stage I, Stage II, or Stage III Breast Cancer Who Are Receiving Paclitaxel | NCT01050075 | Breast Cancer Stage I Breast ... Stage II Breast... Stage IIIA Brea... Stage IIIB Brea... Stage IIIC Brea... | acupuncture the... questionnaire a... management of t... | 18 Years - | City of Hope Medical Center | |
| Evaluation of BNP7787 for the Prevention of Neurotoxicity in Metastatic Breast Cancer Patients Receiving Weekly Paclitaxel | NCT00039780 | Breast Neoplasm... Breast Diseases Metastases, Neo... | BNP7787 Placebo | 18 Years - | BioNumerik Pharmaceuticals, Inc. | |
| Prospective Neurobehavioral Outcomes Follow-up in Primary CNS Lymphoma Patients Treated With Cranial Radiotherapy Combined With or Without MTX-based Chemotherapy According to the Multidisciplinary Treatment Guidelines Implemented at a Single Institute | NCT02655744 | Primary Central... | Standard treatm... | 18 Years - 84 Years | Chang Gung Memorial Hospital | |
| the Effect of ABCC2 Genetic Polymorphism on Neurotoxicity in Gastrointestinal Cancer Patients Receiving Oxaliplatin | NCT05494320 | Gastrointestina... | Folfox Protocol | 18 Years - | Ain Shams University | |
| Electro-acupuncture for the Prevention and Treatment of Oxaliplatin-induced Neurotoxicity in Colorectal Cancer Patients | NCT05798884 | Colorectal Canc... Oxaliplatin Electro-acupunc... Neurotoxicity | Acupuncture Sham-acupunctur... | 18 Years - 80 Years | Hong Kong Baptist University | |
| Liposomal Cytarabine for Central Nervous System (CNS)-Treatment in High-risk Acute Lymphoblastic Leukemia (ALL) | NCT00991744 | Acute Lymphobla... | Liposomal cytar... Intrathecal tri... | 1 Year - 18 Years | Nordic Society for Pediatric Hematology and Oncology | |
| Combination Chemotherapy in Treating Patients With Metastatic Ovarian Cancer or Non-small Cell Lung Cancer | NCT00003072 | Lung Cancer Neurotoxicity Ovarian Cancer | amifostine trih... carboplatin paclitaxel | 18 Years - | University of California, San Francisco | |
| Brain Function in Children Previously Treated on Clinical Trials POG-9605 and POG-9201 | NCT00028509 | Long-term Effec... Neurotoxicity | management of t... | 1 Year - 9 Years | Children's Oncology Group | |
| L-Carnitine L-Tartrate in Preventing Peripheral Neuropathy Caused By Chemotherapy in Women With Metastatic Breast Cancer | NCT00754767 | Breast Cancer Chemotherapeuti... Neurotoxicity | L-carnitine L-t... placebo | 18 Years - 120 Years | HealthPartners Institute | |
| Neurobehavioral Complications in Children Who Were Previously Treated With Steroids and Intrathecal Therapy for Acute Lymphoblastic Leukemia | NCT00085176 | Leukemia Long-term Effec... Neurotoxicity Psychosocial Ef... | management of t... psychosocial as... | 6 Years - 16 Years | Children's Oncology Group | |
| Nerve Function in Older Diabetic Patients Who Are Undergoing Chemotherapy for Metastatic Solid Tumors | NCT00263861 | Neurotoxicity Unspecified Adu... | management of t... | 65 Years - | Case Comprehensive Cancer Center | |
| Treatment Outcome and Quality of Life in Patients With Pediatric Extra-Cranial Germ Cell Tumors Previously Treated on Clinical Trial CCLG-GC-1979-01 or CCLG-GC-1989-01 | NCT00436774 | Childhood Germ ... Extragonadal Ge... Gastrointestina... Infertility Long-term Effec... Neurotoxicity Ovarian Cancer Pulmonary Compl... Sexual Dysfunct... Urinary Complic... | assessment of t... quality-of-life... | 5 Years - | National Cancer Institute (NCI) | |
| A Phase 2 Trial of Anakinra for the Prevention of CAR-T Cell Mediated Neurotoxicity | NCT04150913 | Non Hodgkin Lym... Refractory Non-... Relapsed Non Ho... Neurotoxicity Neurotoxicity S... Cytokine Releas... | Anakinra Axicabtagene Ci... | 18 Years - | Massachusetts General Hospital | |
| Acupuncture in Treating Nerve Pain in Patients With Stage I, Stage II, or Stage III Breast Cancer Who Are Receiving Paclitaxel | NCT01050075 | Breast Cancer Stage I Breast ... Stage II Breast... Stage IIIA Brea... Stage IIIB Brea... Stage IIIC Brea... | acupuncture the... questionnaire a... management of t... | 18 Years - | City of Hope Medical Center | |
| Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy | NCT01099449 | Chemotherapeuti... Colorectal Canc... Neuropathy Neurotoxicity | calcium glucona... magnesium sulfa... placebo oxaliplatin | 18 Years - | Alliance for Clinical Trials in Oncology | |
| Magnetic Resonance Imaging in Immune Effector Cell-Associated Neurotoxicity Syndrome | NCT05510596 | Lymphoma, B-Cel... Neurotoxicity | Magnetic Resona... Blood withdrawa... Neuropsychologi... | 18 Years - | University Hospital, Montpellier | |
| A Pharmacokinetic and Pharmacodynamic Study of Vincristine in Children With Leukemia | NCT00001689 | Acute Lymphocyt... Leukemia | Vincristine | - | National Institutes of Health Clinical Center (CC) | |
| D-cycloserine in the Management of Chemotherapy-Induced Peripheral Neuropathic Pain | NCT00301080 | Neurotoxicity Pain Breast Cancer | D-cycloserine Placebo | 18 Years - | Northwestern University | |
| Magnetic Resonance Imaging in Immune Effector Cell-Associated Neurotoxicity Syndrome | NCT05510596 | Lymphoma, B-Cel... Neurotoxicity | Magnetic Resona... Blood withdrawa... Neuropsychologi... | 18 Years - | University Hospital, Montpellier | |
| Methotrexate, Glucarpidase, and Leucovorin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma | NCT00727831 | Chemotherapeuti... Lymphoma Mucositis Neurotoxicity | glucarpidase leucovorin calc... methotrexate laboratory biom... quality-of-life... radiation thera... | 18 Years - | University College, London | |
| Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors | NCT01445288 | Diffuse Intrins... PNET Ependymoma Germinoma Medulloblastoma | 1 Month - 21 Years | National Institutes of Health Clinical Center (CC) | ||
| Neurotoxicity in Primary Central Nervous System Lymphoma (PCNSL): An International Observational Study of Cognition in Long Term Survivors | NCT00710151 | Primary Central... | 18 Years - 75 Years | OHSU Knight Cancer Institute | ||
| PAINTER: Polymorphism And INcidence of Toxicity in ERibulin Treatment | NCT02864030 | Metastatic Brea... Toxicity Neurotoxicity Drug Toxicity Adverse Drug Ev... | ERIBULIN MESYLA... | 18 Years - | Oncologia Medica dell'Ospedale Fatebenefratelli | |
| Amifostine in Treating Peripheral Neuropathy Caused by Paclitaxel in Patients With Solid Tumors | NCT00078845 | Breast Cancer Lung Cancer Neurotoxicity Ovarian Cancer Prostate Cancer Unspecified Adu... | Amifostine | 18 Years - | M.D. Anderson Cancer Center | |
| Adderall XR Compared With Concerta in Treating Young Cancer Patients With Memory, Attention, and Depression | NCT00069927 | Depression Neurotoxicity Unspecified Chi... | Adderall-XR® Concerta® | 6 Years - 17 Years | University of South Florida | |
| Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma | NCT03696784 | Lymphoma Lymphoma, B-Cel... Immune System D... Immunoprolifera... Lymphatic Disea... | iC9-CAR19 T cel... Bendamustine Fludarabine AP1903 Cyclophosphamid... | 18 Years - | UNC Lineberger Comprehensive Cancer Center | |
| Hearing Loss and Dizziness in Patients Receiving Oxaliplatin for Solid Tumors | NCT00305799 | Neurotoxicity Unspecified Adu... | management of t... | 18 Years - | Case Comprehensive Cancer Center | |
| The Platinum Study Comparison Group | NCT02890030 | Testicular Neop... | Questionnaire | 18 Years - 55 Years | Indiana University | |
| Carboxypeptidase-G2 in Treating Nervous System Toxic Effects in Patients Given an Overdose of Intrathecal Methotrexate | NCT00018967 | Neurotoxicity Unspecified Adu... Unspecified Chi... | glucarpidase | - | National Cancer Institute (NCI) | |
| Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma | NCT03696784 | Lymphoma Lymphoma, B-Cel... Immune System D... Immunoprolifera... Lymphatic Disea... | iC9-CAR19 T cel... Bendamustine Fludarabine AP1903 Cyclophosphamid... | 18 Years - | UNC Lineberger Comprehensive Cancer Center | |
| Adjusting the Dose of Therapeutic Exercise to Prevent Neurotoxicity Due to Anticancer Treatment (ATENTO) | NCT04583124 | Breast Neoplasm | ATENTO-B ATENTO-T | 18 Years - 70 Years | Universidad de Granada | |
| Electrical Stimulation Therapy Using the MC5-A Scrambler in Reducing Peripheral Neuropathy Caused by Chemotherapy | NCT00952848 | Chemotherapeuti... Neurotoxicity Pain Peripheral Neur... Unspecified Adu... | questionnaire a... Sensory Neuropa... Quality of Life... MC5-A Scrambler... | 18 Years - 120 Years | Virginia Commonwealth University | |
| Acute Pain Caused by Paclitaxel in Patients With Cancer | NCT00860041 | Chemotherapeuti... Neurotoxicity Pain Unspecified Adu... | pain questionna... | 18 Years - | Alliance for Clinical Trials in Oncology | |
| Monosialoganglioside(GM1) Preventing Neurotoxicity Induced by Cisplatin Contained Chemotherapy in NSCLC Patients | NCT01882621 | Non-small Cell ... | Monosialogangli... normal saline | - | Sun Yat-sen University | |
| (1)H-Nuclear Magnetic Resonance Spectroscopic Imaging of the Brain in Patients Who Receive Neurotoxic Therapy | NCT00001807 | Brain Cancer Brain Neoplasms | 4 Years - 20 Years | National Institutes of Health Clinical Center (CC) | ||
| L-Carnitine L-Tartrate in Preventing Peripheral Neuropathy Caused By Chemotherapy in Women With Metastatic Breast Cancer | NCT00754767 | Breast Cancer Chemotherapeuti... Neurotoxicity | L-carnitine L-t... placebo | 18 Years - 120 Years | HealthPartners Institute | |
| Study Comparing Weekly Versus Every 3 Week Chemotherapy in Patients With Ovarian Cancer | NCT00660842 | Ovarian Cancer | carboplatin paclitaxel carboplatin paclitaxel | 18 Years - | National Cancer Institute, Naples | |
| Carboxypeptidase-G2 in Treating Nervous System Toxic Effects in Patients Given an Overdose of Intrathecal Methotrexate | NCT00018967 | Neurotoxicity Unspecified Adu... Unspecified Chi... | glucarpidase | - | National Cancer Institute (NCI) | |
| Amifostine in Treating Women With Ovarian, Peritoneal, Cervical, Fallopian Tube, Uterine, or Endometrial Cancer | NCT00003624 | Cervical Cancer Endometrial Can... Fallopian Tube ... Neurotoxicity Ovarian Cancer Primary Periton... Sarcoma | amifostine trih... cisplatin paclitaxel | - | GOG Foundation | |
| Pilot Study of MGd + High-dose MTX-Based Chemoimmunotherapy + RT for Newly Dx PCNSL | NCT00734773 | Brain and Centr... Lymphoma Neurotoxicity | Rituximab Cytarabine Methotrexate Motexafin gadol... Procarbazine hy... Vincristine sul... Radiation thera... | 18 Years - | Northwestern University | |
| Rituximab, Bendamustine Hydrochloride, and Bortezomib Followed by Rituximab and Lenalidomide in Treating Older Patients With Previously Untreated Mantle Cell Lymphoma | NCT01415752 | Lymphoma Neurotoxicity Therapy-related... | rituximab bendamustine hy... bortezomib lenalidomide | 60 Years - 120 Years | Eastern Cooperative Oncology Group | |
| Biomarkers in Predicting Neurotoxicity in Patients With Colorectal Cancer Receiving Oxaliplatin | NCT00884767 | Chemotherapeuti... Colorectal Canc... Neurotoxicity | FOLFOX regimen fluorouracil leucovorin calc... oxaliplatin gene expression... protein express... proteomic profi... laboratory biom... pharmacogenomic... | 18 Years - | National Cancer Institute (NCI) | |
| Dimesna in Treating Patients With Solid Tumors Who Are Undergoing Treatment With Cisplatin and Paclitaxel | NCT00003569 | Head and Neck C... Lung Cancer Neurotoxicity Ovarian Cancer | cisplatin dimesna paclitaxel | 18 Years - | Roswell Park Cancer Institute | |
| Monosialoganglioside(GM1) Preventing Neurotoxicity Induced by Cisplatin Contained Chemotherapy in NSCLC Patients | NCT01882621 | Non-small Cell ... | Monosialogangli... normal saline | - | Sun Yat-sen University | |
| Amifostine in Treating Peripheral Neuropathy in Patients Who Have Received Chemotherapy for Cancer | NCT00058071 | Gestational Tro... Neurotoxicity Peripheral Neur... Unspecified Adu... | amifostine trih... | 18 Years - | GOG Foundation | |
| S0715: Acetyl-L-Carnitine in Preventing Neuropathy in Women With Stage I, II, or IIIA Breast Cancer Undergoing Chemo | NCT00775645 | Breast Cancer Chemotherapeuti... Fatigue Neuropathy Neurotoxicity | acetyl-L-carnit... placebo | 18 Years - 120 Years | SWOG Cancer Research Network | |
| Amifostine in Treating Women With Ovarian, Peritoneal, Cervical, Fallopian Tube, Uterine, or Endometrial Cancer | NCT00003624 | Cervical Cancer Endometrial Can... Fallopian Tube ... Neurotoxicity Ovarian Cancer Primary Periton... Sarcoma | amifostine trih... cisplatin paclitaxel | - | GOG Foundation | |
| Duloxetine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer | NCT00489411 | Neurotoxicity Pain Peripheral Neur... Unspecified Adu... | duloxetine hydr... placebo | 25 Years - | Alliance for Clinical Trials in Oncology | |
| Monosialotetrahexosylganglioside for Treatment of Oxaliplatin Induced Neurotoxicity in Gastrointestinal Cancer | NCT02486198 | Neurotoxicity | placebo GM oxaliplatin-bas... | 18 Years - | Tianjin Medical University Cancer Institute and Hospital | |
| Heavy Metal Exposure in Predicting Peripheral Neuropathy in Patients With Stage I-III Breast Cancer Undergoing Chemotherapy | NCT01982591 | Male Breast Can... Neurotoxicity Peripheral Neur... Stage IA Breast... Stage IB Breast... Stage II Breast... Stage IIIA Brea... Stage IIIB Brea... Stage IIIC Brea... | laboratory biom... questionnaire a... | 18 Years - | Fox Chase Cancer Center | |
| Study Comparing Weekly Versus Every 3 Week Chemotherapy in Patients With Ovarian Cancer | NCT00660842 | Ovarian Cancer | carboplatin paclitaxel carboplatin paclitaxel | 18 Years - | National Cancer Institute, Naples | |
| Lamotrigine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer | NCT00068445 | Neurotoxicity Pain Unspecified Adu... | lamotrigine Placebo | 18 Years - | Alliance for Clinical Trials in Oncology | |
| Acute Pain Caused by Paclitaxel in Patients With Cancer | NCT00860041 | Chemotherapeuti... Neurotoxicity Pain Unspecified Adu... | pain questionna... | 18 Years - | Alliance for Clinical Trials in Oncology | |
| Prospective Neurobehavioral Functions in Newly-diagnosed Patients With Primary CNS Lymphoma Treated With Hyperfractionated Conformal Whole-brain Radiation Therapy Plus Simultaneous Integrated Boost | NCT04006561 | Primary CNS Lym... Brain Lymphoma | A treatment pro... | 18 Years - 80 Years | Chang Gung Memorial Hospital | |
| Nerve Changes in Patients Who Are Undergoing Chemotherapy or Biological Therapy for Cancer | NCT00281853 | Neurotoxicity Unspecified Adu... | management of t... | 21 Years - 85 Years | Case Comprehensive Cancer Center | |
| S0715: Acetyl-L-Carnitine in Preventing Neuropathy in Women With Stage I, II, or IIIA Breast Cancer Undergoing Chemo | NCT00775645 | Breast Cancer Chemotherapeuti... Fatigue Neuropathy Neurotoxicity | acetyl-L-carnit... placebo | 18 Years - 120 Years | SWOG Cancer Research Network | |
| Evaluation of BNP7787 for the Prevention of Neurotoxicity in Metastatic Breast Cancer Patients Receiving Weekly Paclitaxel | NCT00039780 | Breast Neoplasm... Breast Diseases Metastases, Neo... | BNP7787 Placebo | 18 Years - | BioNumerik Pharmaceuticals, Inc. | |
| Prospective Neurobehavioral Outcomes Follow-up in Primary CNS Lymphoma Patients Treated With Cranial Radiotherapy Combined With or Without MTX-based Chemotherapy According to the Multidisciplinary Treatment Guidelines Implemented at a Single Institute | NCT02655744 | Primary Central... | Standard treatm... | 18 Years - 84 Years | Chang Gung Memorial Hospital | |
| EGb761 in Maintaining Mental Clarity in Women Receiving Chemotherapy for Newly Diagnosed Breast Cancer | NCT00046891 | Breast Cancer Neurotoxicity | Ginkgo Biloba Placebo | 18 Years - | Alliance for Clinical Trials in Oncology | |
| Biomarkers in Predicting Neurotoxicity in Patients With Colorectal Cancer Receiving Oxaliplatin | NCT00884767 | Chemotherapeuti... Colorectal Canc... Neurotoxicity | FOLFOX regimen fluorouracil leucovorin calc... oxaliplatin gene expression... protein express... proteomic profi... laboratory biom... pharmacogenomic... | 18 Years - | National Cancer Institute (NCI) | |
| Dimesna in Treating Patients With Solid Tumors Who Are Undergoing Treatment With Cisplatin and Paclitaxel | NCT00003569 | Head and Neck C... Lung Cancer Neurotoxicity Ovarian Cancer | cisplatin dimesna paclitaxel | 18 Years - | Roswell Park Cancer Institute | |
| Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy | NCT01099449 | Chemotherapeuti... Colorectal Canc... Neuropathy Neurotoxicity | calcium glucona... magnesium sulfa... placebo oxaliplatin | 18 Years - | Alliance for Clinical Trials in Oncology | |
| Vitamin E in Preventing Peripheral Neuropathy Caused by Chemotherapy in Patients Receiving Chemotherapy for Cancer | NCT00363129 | Neurotoxicity Unspecified Adu... | vitamin E placebo | 18 Years - | Alliance for Clinical Trials in Oncology | |
| D-cycloserine in the Management of Chemotherapy-Induced Peripheral Neuropathic Pain | NCT00301080 | Neurotoxicity Pain Breast Cancer | D-cycloserine Placebo | 18 Years - | Northwestern University | |
| Molecular-Genetic Mechanisms Associated With Chemotherapy-Induced Nerve Damage | NCT01293851 | Peripheral Neur... Neurotoxicity Cancer | 18 Years - | National Institutes of Health Clinical Center (CC) | ||
| Amifostine in Treating Peripheral Neuropathy in Patients Who Have Received Chemotherapy for Cancer | NCT00058071 | Gestational Tro... Neurotoxicity Peripheral Neur... Unspecified Adu... | amifostine trih... | 18 Years - | GOG Foundation |
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