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Brief Title: An Open-Label Phase 1/2 Study of Itacitinib in Combination With Osimertinib in Subjects With Non-Small Cell Lung Cancer
Official Title: An Open-Label Phase 1/2 Study of Itacitinib in Combination With Osimertinib in Subjects With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Study ID: NCT02917993
Brief Summary: The purpose of this study is to evaluate the safety and tolerability of itacitinib in combination with osimertinib in subjects with locally advanced or metastatic non-small cell lung cancer (NSCLC).
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
University of California San Diego, 3855 Health Sciences Drive, Mc 0987, La Jolla, California, United States
University California San Francisco Thoracic Surgery and Oncology Clinic, 1600 Divisadero Street, Floor 4, San Francisco, California, United States
Innovative Clinical Research Institute, 15111 Whittier Blvd., Suite 216, Whittier, California, United States
Rocky Mountain Cancer Center, 1800 Williams Street, Suite 200, Denver, Colorado, United States
Georgetown University Hospital, 3800 Reservoir Rd, NW, Washington, District of Columbia, United States
Lynn Cancer Center, 701 NW 13th Street, Floor 2, Boca Raton, Florida, United States
Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts, United States
Henry Ford Health System, 2799 W Grand Blvd., Detroit, Michigan, United States
Karmanos Cancer Institute, 4100 John R. street mail Code HW04HO, Detroit, Michigan, United States
Valley Hospital, 223 N Van Dien Avenue, Ridgewood, New Jersey, United States
NYU Langone Medical Center, 160 East 34th Street, Floor 8, New York, New York, United States
Stony Brook University Medical Center, 3 Edmund D. Pellegrino Road, Stony Brook, New York, United States
Cleveland Clinic, 9500 Euclid Avenue, G Building, Cleveland, Ohio, United States
Earle A. Chiles Research Institute Providence Cancer Center, 4805 NE Glisan Street, 2N35, Portland, Oregon, United States
St. Luke's University Health Network, 701 Ostrum Street, Suite 403, Fountain Hill, Pennsylvania, United States
Thomas Jefferson University, 111 S. 11th Street, Philadelphia, Pennsylvania, United States
Texas Oncology - South Austin, 901 West 38th Street, Suite 200, Austin, Texas, United States
University of Texas -MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas, United States
Texas Oncology - San Antonio Medical, 5206 Research Drive, San Antonio, Texas, United States
Texas Oncology-Tyler, 910 E Houston Street, Suite 100, Tyler, Texas, United States
Huntsman Cancer Institute, 2000 Circle of Hope Drive, Salt Lake City, Utah, United States
US Oncology-Virginia Cancer Specialists, PC, 8503 Arlington Blvd., Suite 400, Fairfax, Virginia, United States
West Virginia University Cancer Institute, 1 Medical Center Drive, Morgantown, West Virginia, United States
The catholic University of Korea, Seoul St. Mary's hospital, 222 Banpo-daero, Seoul, Seocho-gu, Korea, Republic of
Severance Hospital, Yonsei University Health System 50-1 Yonsei-ro, Seoul, Seodaemun-gu, Korea, Republic of
Asan Medical Center Department of Oncology, 88, Olympic-ro 43-gil, Seoul, Songpa-gu, Korea, Republic of
Antiga Guarderia-Servei d'Oncologia Hospital Vall d'Hebron. P.Vall Hebron 119-129, Barcelona, , Spain
Hospital Ramón y Cajal Ctra. Colmenar Viejo Km. 9,1 Planta (-)2 Dcha Oficina de Ensayos Clínicos Servicio de Oncología Médica, Madrid, , Spain
Hospital Clinico Universitario Valencia Avenida Blasco Ibáñez 17 -8º, Valencia, , Spain
Taipei Veterans General Hospital, No.201 Sec. 2 Shipai Rd l, Taipei City, Beitou District, Taiwan
National Taiwan University Hospital, 7 Zhongshan South Road, Taipei, Zhongzheng District, Taiwan
Name: Peter Langmuir
Affiliation: Incyte Corporation
Role: STUDY_DIRECTOR