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Spots Global Cancer Trial Database for Evaluating the Pulmonary Nodule With Imaging and Biomarkers

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Trial Identification

Brief Title: Evaluating the Pulmonary Nodule With Imaging and Biomarkers

Official Title: Evaluating the Pulmonary Nodule With Imaging and Biomarkers

Study ID: NCT01739881

Conditions

Lung Cancer

Study Description

Brief Summary: The study aims to determine if there are defining EBUS and confocal endoscopy features as well as exhaled alveolar gas VOC that can discriminate malignant pulmonary nodules or masses from benign etiology, thereby obviating unnecessary thoracotomy. Directly sampled alveolar gas VOC from patients with lung cancer will be compared against exhaled breath VOC for signature compounds that may complement CT in screening the population at risk.

Detailed Description: AIMS 1. To improve diagnostic yield of pulmonary nodule or mass by using combined approach of navigation bronchoscopy and EBUS. 2. To determine if characteristic features of EBUS and confocal microendoscopy exist as well as VOC patterns in alveolar and exhaled gas that can aid in discriminating malignant pulmonary nodule or mass from benign etiology by correlating with pathology. 3. To identify VOC patterns specific for lung cancer by correlating VOC from directly sampled alveolar gas and exhaled breath with pathology. Exhaled breath VOC signature may complement CT in screening population at risk.

Eligibility

Minimum Age: 21 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

National University Hospital/ National University of Singapore, Singapore, , Singapore

Contact Details

Name: Pyng Lee, MD

Affiliation: National University Hospital, Singapore

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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