Spots Global Cancer Trial Database for The Lung PCA: A Multi-Dimensional Atlas of Pulmonary Premalignancy

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Trial Identification

Brief Title: The Lung PCA: A Multi-Dimensional Atlas of Pulmonary Premalignancy

Official Title: The Lung PCA: A Multi-Dimensional Atlas of Pulmonary Premalignancy

Study ID: NCT03881098

Conditions

Lung Cancer

Interventions

Bronchoscopies

Sputum Sample

Venipuncture

Study Description

Brief Summary: This protocol pertains specifically to the prospective lung squamous cell carcinoma pre-malignant lesion (PML) cohort that will form a primary study group for the Lung Pre-Cancer Atlas.

Detailed Description: Via pre-screening, subjects at high risk for the development of lung squamous cell carcinoma (SCC) will be identified and enrolled to undergo serial bronchoscopies at 12 month intervals over a 2-3 year period. A variety of specimen types will be collected to support analyses of the genomic and microenvironmental features of these PMLs.