Spots Global Cancer Trial Database for Effects of Exercise Training in Survivors of Lymphoma

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Trial Identification

Brief Title: Effects of Exercise Training in Survivors of Lymphoma

Official Title: The LYMfit Study: Exercise Training to Prevent Cardiovascular Disease in Lymphoma Survivors

Study ID: NCT06270667

Conditions

Lymphoma

Physical Exercise

Cardiotoxicity

Cardiovascular Diseases

Chemotherapeutic Toxicity

Interventions

Aerobic Exercise

Combined Aerobic and Resistance Exercise

Study Description

Brief Summary: This study aims to compare the effects of aerobic exercise with or without addition of resistance exercise to usual care in individuals treated with anthracyclines for lymphomas and to compare exercise effects to age- and sex-matched individuals with no prior history of malignant diseases.

Detailed Description: In this study, a comparison of the exercise effects between individuals previously treated for specific lymphoma diagnoses and individuals with no history of cancer will be conducted. Therefore, in addition to a randomized controlled trial in individuals with a previous lymphoma diagnosis (i.e., exercise groups and a non-exercising control group), a reference group comprising age- and sex-matched individuals with no history of a cancer diagnosis will also be included. Participants in the reference group will undergo the same exercise intervention as the aerobic exercise group. This study recruits through invitation only. The primary endpoint in this study is the change in cardiorespiratory fitness, assessed as VO2peak. Secondary endpoints include common risk factors for cardiovascular disease and cardiometabolic health, other variables derived from the cardiopulmonary exercise test and lung function assessments, and muscle cellular endpoints from muscle biopsies obtained from m. vastus lateralis, in addition to patient-reported outcomes.