Spots Global Cancer Trial Database for cardiotoxicity
Every month we try and update this database with for cardiotoxicity cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Cardiac Dysfunction in Childhood Cancer Survivors | NCT03790943 | Cardiac Dysfunc... Cardiovascular ... Childhood Cance... | cardiac assessm... | 18 Years - | University of Bern | |
| The Harmonized Interventions to Maintain Health Via Appropriate Risk Factor Modification and Lifestyle Changes in Pediatric, Adolescent and Young Adult Cancer Survivors Pilot Study | NCT04598646 | Heart Failure Cardiotoxicity Cancer | Cardio-oncology... Support | 18 Years - 45 Years | University Health Network, Toronto | |
| The Impact of Chronic Mitochondrial Antioxidant Supplementation on CardiovascularToxicity in Breast Cancer Patients | NCT05146843 | Breast Neoplasm... | Mitoquinone Placebo | 18 Years - 75 Years | D'Or Institute for Research and Education | |
| STOP Heart Disease in Breast Cancer Survivors Trial | NCT02674204 | Breast Cancer Heart Disease Cardiotoxicity Myocardial Dysf... | Atorvastatin Placebo | 18 Years - | Cedars-Sinai Medical Center | |
| Mechanisms, Predictors, and Social Determinants of Cardiotoxicity in Prostate Cancer | NCT05096338 | Prostate Cancer Cardiotoxicity Drug-Related Si... Cardiovascular ... | Social Determin... | 18 Years - | Abramson Cancer Center at Penn Medicine | |
| Clinical and Diagnostic Significance of Endothelial Dysfunction and Myocardial Contractility in Patients With AML | NCT05703126 | Acute Myeloid L... Cardiotoxicity Endothelial Dys... | History taking Anthropometry Complete blood ... Biochemical blo... Coagulogram Immunoenzymatic... Stress echocard... Triplex scannin... Electrocardiogr... Ultrasound of t... Cytogenetic exa... Cytological exa... Immunophenotypi... Determination o... laser Doppler f... | 18 Years - 65 Years | Samara State Medical University | |
| Hyperpolarized Carbon 13-Based Metabolic Imaging to Detect Radiation-Induced Cardiotoxicity | NCT04044872 | Thoracic Cancer Left Sided Brea... | [1-13C]pyruvate... | 18 Years - | University of Texas Southwestern Medical Center | |
| Cardiotoxicity in Locally Advanced Lung Cancer Patients Treated With Chemoradiation Therapy | NCT04305613 | Cardiotoxicity Lung Cancer Sta... Lung Cancer Sta... Radiation Toxic... | Chemoradiation | 18 Years - | Abramson Cancer Center at Penn Medicine | |
| Adverse Myocardial and Vascular Side Effects of Immune Checkpoint Inhibitors | NCT04586894 | Cancer Immune Defect Cardiovascular ... | Cardiac MRI Smart cloth Biobanking | 18 Years - | Assistance Publique - Hôpitaux de Paris | |
| Novel Biomarkers and Echocardiography for Subclinical Cardiac Toxicity in Breast Cancer Patients Receiving Anthracyclines | NCT03155802 | Cardiotoxicity Heart Failure Breast Cancer Anthracycline I... Biomarkers Echocardiograph... | 18 Years - 85 Years | Stony Brook University | ||
| Cardiovascular Effects of CART Cell Therapy | NCT04026737 | Leukemia Lymphoma Cardiotoxicity Risk Factor, Ca... Immunotherapy | 18 Years - | Abramson Cancer Center at Penn Medicine | ||
| Strategy Therapy on Cancer Therapy-Related Cardiac Dysfunction | NCT05892146 | Chemotherapeuti... Cardiotoxicity Heart Failure Breast Cancer Lymphoma | Prevention ther... Rescue therapy | 20 Years - 65 Years | National Cheng-Kung University Hospital | |
| Effect of Remote Ischaemic Conditioning in Oncology Patients | NCT02471885 | Cardiotoxicity | Remote Ischaemi... Placebo | 16 Years - 80 Years | University College, London | |
| Statins for the Primary Prevention of Heart Failure in Patients Receiving Anthracycline Pilot Study | NCT03186404 | Cancer Heart Failure Cardiotoxicity | Atorvastatin Placebo oral ta... | 18 Years - | University Health Network, Toronto | |
| Effect of Angiotensin Converting Enzyme and Sacubitril Valsartan in Patients After Bone Marrow Transplantation | NCT04092309 | Hematopoietic S... Cardiotoxicity | ACE inhibitor, ... | 18 Years - | University of Athens | |
| Effect of Physical Training in Patients With Heart Failure Caused by Chemotherapy for Cancer Treatment | NCT04047901 | Insufficiency;C... Cancer Cardiotoxicity Heart Failure | exercise traini... | 18 Years - | University of Sao Paulo General Hospital | |
| Prevention of Chest Pain in Chemo-treated Cancer Patients | NCT03486340 | Solid Carcinoma 5-Fluorouracil ... Cardiotoxicity Chemotherapeuti... Acute Coronary ... Coronary Artery... Chest Pain | Cardiologic ass... | 18 Years - | Vejle Hospital | |
| Investigating the Long-term Cardiac Sequelae of Trastuzumab Therapy | NCT05019365 | Breast Cancer HER2-positive B... Cardiotoxicity | 18 Years - | University of Glasgow | ||
| Exercise to Prevent AnthraCycline-based Cardio-Toxicity Study 2.0 (EXACT2) | NCT03748550 | Cancer, Breast Cardiotoxicity Cardiovascular ... | Aerobic exercis... | 18 Years - | Nova Scotia Health Authority | |
| Can Flaxseed Prevent Broken Hearts in Women With Breast Cancer Study? | NCT04632407 | Cardiotoxicity | Flax "milk" Oat fibre "milk... | 18 Years - | St. Boniface Hospital | |
| Understanding CARdiac Events in Breast Cancer | NCT05921279 | Breast Cancer Cardiotoxicity Cardiomyopathie... Chemotherapeuti... Heart Failure Oncology | 18 Years - 90 Years | National University of Ireland, Galway, Ireland | ||
| Statins for the Primary Prevention of Heart Failure in Patients Receiving Anthracycline Pilot Study | NCT03186404 | Cancer Heart Failure Cardiotoxicity | Atorvastatin Placebo oral ta... | 18 Years - | University Health Network, Toronto | |
| Circulating MicroRNA as Biomarker of Cardiotoxicity in Breast Cancer | NCT02065908 | Breast Cancer | 18 Years - 70 Years | West Pomeranian Cancer Center | ||
| Cardiovascular Assessment of Pediatric Cancer Survivors | NCT05939089 | Left Ventricula... Heart Failure | ECG, Echocardio... | 18 Years - | Istanbul University | |
| Cardioprotective Effect of Acute Exercise in Breast Cancer Patients | NCT05467111 | Early-stage Bre... | Acute Exercise | 18 Years - | Technical University of Madrid | |
| Effect of Genetic and Epigenetic Factors on the Clinical Response and Toxicity to Doxorubicin Among Egyptian Breast Cancer Patients | NCT05733026 | Breast Cancer | 18 Years - 80 Years | Ain Shams University | ||
| The HIMALAYAS Trial and Lifestyle Changes in Pediatric, Adolescent and Young Adult Cancer Survivors Study: A Multicentre Randomized Controlled Trial | NCT05023785 | Heart Failure Cardiotoxicity Cancer | Cardio-oncology... | 18 Years - 45 Years | University Health Network, Toronto | |
| Nicotinamide Riboside and Prevention of Cancer Therapy Related Cardiac Dysfunction in Breast Cancer Patients | NCT05732051 | Breast Cancer Metastatic Brea... Cancer Therapy-... Cardiotoxicity Heart Failure | Nicotinamide Ri... Placebo | 18 Years - | University Hospital, Akershus | |
| The HIMALAYAS Trial and Lifestyle Changes in Pediatric, Adolescent and Young Adult Cancer Survivors Study: A Multicentre Randomized Controlled Trial | NCT05023785 | Heart Failure Cardiotoxicity Cancer | Cardio-oncology... | 18 Years - 45 Years | University Health Network, Toronto | |
| Cancer Adverse Effects PReventIon With Care & Exercise: the CAPRICE Study | NCT03850171 | Breast Neoplasm... Lymphoma Cardiotoxicity Anthracyclines Physical Activi... | Exercise Traini... | 18 Years - | Insel Gruppe AG, University Hospital Bern | |
| Effect of Anthracyclines and Cyclophosphamide on Cardiovascular Responses | NCT04568161 | Cardiotoxicity Cardiovascular ... Neurovascular D... Endothelial Dis... Breast Cancer | Physical Charac... Muscular Sympat... Cardiac Functio... Heart rate Blood pressure Blood Assessmen... Muscle blood fl... Endothelium-dep... Vascular intima... Physical Capaci... Anthracycline &... | 45 Years - 60 Years | University of Sao Paulo General Hospital | |
| Hypertension and Arrhythmias in CLL Patients Treated With BTK Inhibitors | NCT06211413 | Chronic Lymphoc... Atrial Fibrilla... Hypertension Cardiotoxicity | no intervention | 22 Years - | Abramson Cancer Center at Penn Medicine | |
| Cardiovascular Function in Acute Leukemia | NCT03760237 | Leukemia, Myelo... Leukemia, Lymph... Cardiotoxicity | observation onl... | 18 Years - 90 Years | Abramson Cancer Center at Penn Medicine | |
| Breast Cancer Long-term Outcome of Cardiac Dysfunction | NCT01904331 | Breast Neoplasm... | 18 Years - | University Medical Center Groningen | ||
| PROactive Evaluation of Function to Avoid CardioToxicity | NCT03862131 | Cardiotoxicity Breast Cancer Lymphoma Sarcoma Leukemia Myeloma Lung Cancer | MyoStrain® | 18 Years - | Washington University School of Medicine | |
| Improving the Success Rate for Thoracic Radiotherapy Through Specific Cardiac Substructure Dosimetry: Location Matters. (LOCATION MATTERS) | NCT06361784 | Locally Advance... | - | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | ||
| cARdiotoxicity Profile of aBIraTeRone in prostAte Cancer : a pharmacoviGilancE Study | NCT03243604 | Arrhythmias, Ca... Atrial Fibrilla... Tachycardia, Su... Cardiac Failure | L02 (sex hormon... | 18 Years - | Groupe Hospitalier Pitie-Salpetriere | |
| Cancer Therapy Effects on the Heart | NCT04262830 | Cardiotoxicity Pediatric Cance... Heart Failure | Cardiac magneti... Echocardiograph... Electrocardiogr... | 13 Years - 39 Years | University of California, San Diego | |
| Exercise to Prevent AnthraCycline-based Cardio-Toxicity Study 2.0 (EXACT2) | NCT03748550 | Cancer, Breast Cardiotoxicity Cardiovascular ... | Aerobic exercis... | 18 Years - | Nova Scotia Health Authority | |
| Myocet Plus Endoxan for Older Patients With Breast Cancer | NCT01120171 | Breast Cancer | Cyclophosphamid... Liposomal-encap... | 18 Years - | Hellenic Oncology Research Group | |
| Anthracycline Induced Cardiotoxicity - Early Detection by Combination of Diastolic Strain and T2-mapping | NCT03940625 | Breast Cancer Myocardial Dama... Cardiotoxicity | Cardiac MRI and... | 18 Years - | Heinrich-Heine University, Duesseldorf | |
| Protective Effects of the Nutritional Supplement Sulforaphane on Doxorubicin-Associated Cardiac Dysfunction | NCT03934905 | Anthracycline R... | sulforaphane Placebo Oral Ta... | 18 Years - 89 Years | Texas Tech University Health Sciences Center | |
| Cardiotoxicity Prevention in Breast Cancer Patients Treated With Anthracyclines and/or Trastuzumab | NCT02236806 | Breast Cancer Cardiotoxicity | Bisoprolol Ramipril Placebo | 18 Years - | Azienda Ospedaliero-Universitaria Careggi | |
| Assessment of Cardiotoxicity After Chemotherapy for Breast Cancer by Cardio-vascular Magnetic Resonance (MR) | NCT00679874 | Breast Cancer | Cardio-vascular... | - | University of Calgary | |
| The STOP-MED CTRCD Trial | NCT06183437 | Heart Failure Cardiotoxicity Cardiac Toxicit... Antineoplastics... Cancer | Stopping Heart ... | 18 Years - | University Health Network, Toronto | |
| Evaluation of Reporting of Cardio-vascular Adverse Events With Antineoplastic and Immunomodulating Agents (EROCA) | NCT03530215 | Cardiac Disease Cancer | Antineoplastic ... | 0 Years - 100 Years | Groupe Hospitalier Pitie-Salpetriere | |
| Strain Echocardiography to Predict Cardiotoxicity in Patients Receiving Chemotherapy Containing Doxorubicin | NCT02423356 | Breast Neoplasm... Lymphoma Sarcoma | Echocardiogram | 18 Years - | Indiana University | |
| Statins for the Primary Prevention of Heart Failure in Patients Receiving Anthracycline Pilot Study | NCT03186404 | Cancer Heart Failure Cardiotoxicity | Atorvastatin Placebo oral ta... | 18 Years - | University Health Network, Toronto | |
| Multidisciplinary Approach to Novel Therapies in Cardiology Oncology Research | NCT01016886 | Breast Cancer Heart Failure | perindopril OR ... | 18 Years - | AHS Cancer Control Alberta | |
| Effects of Carvedilol on Cardiotoxicity in Cancer Patients Submitted to Anthracycline Therapy | NCT04939883 | Cancer | Carvedilol Placebo | 18 Years - | Hospital Sirio-Libanes | |
| Role of Aerobic Exercise to Modulate Cardiotoxicity in Long Term Cancer Survivors Exposed to Anthracycline Therapy | NCT04036032 | Cancer Cardiotoxicity | Exercise progra... | 9 Years - 99 Years | Connecticut Children's Medical Center | |
| Protective Effects of the Nutritional Supplement Sulforaphane on Doxorubicin-Associated Cardiac Dysfunction | NCT03934905 | Anthracycline R... | sulforaphane Placebo Oral Ta... | 18 Years - 89 Years | Texas Tech University Health Sciences Center | |
| Effect of Spironolactone in the Prevention of Anthracycline-induced Cardiotoxicity (SPIROTOX) | NCT06005259 | Cardiotoxicity Neoplasms Chemotherapy Ef... Heart Failure | Spironolactone Placebo | 18 Years - | University of Sao Paulo | |
| STOP Heart Disease in Breast Cancer Survivors Trial | NCT02674204 | Breast Cancer Heart Disease Cardiotoxicity Myocardial Dysf... | Atorvastatin Placebo | 18 Years - | Cedars-Sinai Medical Center | |
| Mechanisms, Predictors, and Social Determinants of Cardiotoxicity in Prostate Cancer | NCT05096338 | Prostate Cancer Cardiotoxicity Drug-Related Si... Cardiovascular ... | Social Determin... | 18 Years - | Abramson Cancer Center at Penn Medicine | |
| Cardiotoxicity Monitoring With Single-lead Electrocardiogram | NCT05676606 | Cardiotoxicity | Remote 1-minute... | 18 Years - 90 Years | I.M. Sechenov First Moscow State Medical University | |
| Effects of Exercise Training in Survivors of Lymphoma | NCT06270667 | Lymphoma Physical Exerci... Cardiotoxicity Cardiovascular ... Chemotherapeuti... | Aerobic Exercis... Combined Aerobi... | 20 Years - 70 Years | Norwegian School of Sport Sciences | |
| Effect of Anthracyclines and Cyclophosphamide on Cardiovascular Responses | NCT04568161 | Cardiotoxicity Cardiovascular ... Neurovascular D... Endothelial Dis... Breast Cancer | Physical Charac... Muscular Sympat... Cardiac Functio... Heart rate Blood pressure Blood Assessmen... Muscle blood fl... Endothelium-dep... Vascular intima... Physical Capaci... Anthracycline &... | 45 Years - 60 Years | University of Sao Paulo General Hospital | |
| Multidisciplinary Approach to Novel Therapies in Cardiology Oncology Research | NCT01016886 | Breast Cancer Heart Failure | perindopril OR ... | 18 Years - | AHS Cancer Control Alberta | |
| Anthracycline Induced Cardiotoxicity - Early Detection by Combination of Diastolic Strain and T2-mapping | NCT03940625 | Breast Cancer Myocardial Dama... Cardiotoxicity | Cardiac MRI and... | 18 Years - | Heinrich-Heine University, Duesseldorf | |
| Late Anthracycline Induced Cardiotoxicity- Childhood Cancer Survivors | NCT04852965 | Anthracycline I... | 18 Years - | Queen's University, Belfast | ||
| Prevention of Chest Pain in Chemo-treated Cancer Patients | NCT03486340 | Solid Carcinoma 5-Fluorouracil ... Cardiotoxicity Chemotherapeuti... Acute Coronary ... Coronary Artery... Chest Pain | Cardiologic ass... | 18 Years - | Vejle Hospital | |
| Carvedilol Effect in Preventing Chemotherapy - Induced Cardiotoxicity | NCT01724450 | Breast Cancer Heart Failure Cardiotoxicity | Carvedilol Placebo | 18 Years - | University of Sao Paulo | |
| Cardiac Dysfunction in Childhood Cancer Survivors | NCT03790943 | Cardiac Dysfunc... Cardiovascular ... Childhood Cance... | cardiac assessm... | 18 Years - | University of Bern | |
| Evaluation of Reporting of Cardio-vascular Adverse Events With Antineoplastic and Immunomodulating Agents (EROCA) | NCT03530215 | Cardiac Disease Cancer | Antineoplastic ... | 0 Years - 100 Years | Groupe Hospitalier Pitie-Salpetriere | |
| Usefulness of Myocardial Deformation Imaging for Trastuzumab-induced Cardiotoxicity | NCT01665300 | Left Ventricula... Cardiotoxicity | 18 Years - 75 Years | Seoul National University Hospital | ||
| Defining Robust Predictors of Chemotherapy Related Cardiotoxicity | NCT05159479 | Cardiotoxicity Gastrointestina... | 18 Years - | University College, London | ||
| Cardiovascular Prevention Strategies in Elderly Patients With Cancer (CARTIER Clinical Trial) | NCT03711110 | Cancer (Colon C... Elderly Antineoplastic ... Cardiotoxicity | Intensive cardi... No intervention | 65 Years - | Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León | |
| CAR T Cell Therapy Related Cardiovascular Outcomes | NCT05130489 | Cardiovascular ... B-cell Acute Ly... B-cell Lymphoma... B-cell Lymphoma... Primary Mediast... Diffuse Large B... Cardiotoxicity Cardiovascular ... | 16 Years - | University College London Hospitals | ||
| Multimodal Assesment of Acute Cardiac Toxicity Induced by Thoracic Radiotherapy in Cancer Patients | NCT04896242 | Radiotherapy; C... Cardiotoxicity Cancer Lung Cancer Breast Cancer Esophageal Canc... | 18 Years - | Pontificia Universidad Catolica de Chile | ||
| Hyperpolarized Carbon 13-Based Metabolic Imaging to Detect Radiation-Induced Cardiotoxicity | NCT04044872 | Thoracic Cancer Left Sided Brea... | [1-13C]pyruvate... | 18 Years - | University of Texas Southwestern Medical Center | |
| Evaluation of Myocardial Injury After Anthracycline Chemotherapy in Osteosarcoma Patients Using CMR | NCT04461223 | Cardiotoxicity Osteosarcoma Myocardial Inju... Chemotherapy In... Doxorubicin Ind... | contrast-enhanc... | 8 Years - 50 Years | Second Affiliated Hospital, School of Medicine, Zhejiang University | |
| The STOP-MED CTRCD Trial | NCT06183437 | Heart Failure Cardiotoxicity Cardiac Toxicit... Antineoplastics... Cancer | Stopping Heart ... | 18 Years - | University Health Network, Toronto | |
| Smart Home Care of Cloud Base ECG on the Cardiotoxicity Prevention on the Cancer Patients. | NCT04885088 | Artificial Inte... Cardiotoxicity Cardiac Monitor Cancer Treatmen... ECG | Wisdom bracelet | 20 Years - | Taipei Medical University Shuang Ho Hospital | |
| Evaluation of the Cardioprotective Effect of L-carnitine and Silymarin in Patients Receiving Anthracycline Chemotherapy | NCT04434404 | Breast Cancer | L-Carnitine 500... | 20 Years - 60 Years | Horus University | |
| Early Identification and Evaluation of Cyclophosphamide Cardiotoxicity | NCT05150080 | Cardio-oncology Hematopoietic S... Cardiotoxicity Cyclophosphamid... Echocardiograph... | - 14 Years | Qianfoshan Hospital | ||
| Effect of Genetic and Epigenetic Factors on the Clinical Response and Toxicity to Cisplatin Among Egyptian Non-small Cell Lung Cancer Patients | NCT05746598 | Non Small Cell ... Nephropathy Cardiotoxicity | Cisplatin injec... | 18 Years - 80 Years | Ain Shams University | |
| Early Detection of Broken Hearts in Cancer Patients | NCT02086695 | Cardiotoxicity | 18 Years - 90 Years | Mayo Clinic | ||
| Global Cardio Oncology Registry | NCT05598879 | Breast Cancer Hematologic Mal... Immune Checkpoi... Cardiotoxicity Cardiovascular ... | anonymized data... | 18 Years - | The Cleveland Clinic | |
| Empagliflozin in the Prevention of Cardiotoxicity in Cancer Patients Undergoing Chemotherapy Based on Anthracyclines | NCT05271162 | Cardiotoxicity | Empagliflozin 1... Placebo | 18 Years - | Maria Sklodowska-Curie National Research Institute of Oncology |
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