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Brief Title: Phase I Study of MLN8237 and Pazopanib in Patients With Solid Tumors
Official Title: STM-01: Phase I EffTox Study of Aurora A Kinase Inhibitor Alisertib (MLN8237) Given in Combination With Selective VEGFR Inhibitor Pazopanib (Votrient) for Therapy of Solid Tumors
Study ID: NCT01639911
Brief Summary: This phase I trial using the EffTox design will evaluate activity and safety of alisertib, an Aurora A kinase inhibitor, when given in combination with the selective VEGFR inhibitor pazopanib in patients with advanced, previously treated non-hematologic solid tumors.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
University of Illinois Cancer Center, Chicago, Illinois, United States
Name: Arkadiusz Z. Dudek, M.D.
Affiliation: University of Illinois at Chicago
Role: PRINCIPAL_INVESTIGATOR