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Spots Global Cancer Trial Database for Engagement of American Indians of Southwestern Tribal Nations in Cancer Genome Sequencing

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Trial Identification

Brief Title: Engagement of American Indians of Southwestern Tribal Nations in Cancer Genome Sequencing

Official Title: Participant Engagement - Cancer Genome Sequencing (PE-CGS) Research Center: Engagement of American Indians of Southwestern Tribal Nations in Cancer Genome Sequencing

Study ID: NCT06207864

Study Description

Brief Summary: This clinical trial studies engagement strategies for recruiting American Indians (AI) of Southwestern Tribal Nations for cancer genome sequencing. American Indians in the Southwest have higher rates of some types of cancer, such as cancers that arise in the liver, kidney, breast, and colon. American Indians with cancer may also live for less time than people from other population groups who have been treated for the same cancer. Damage to the cells of the body, acquired as people live, grow older, and are exposed to the environment, causes genetic changes in cells that can lead to cancer. This study may help researchers learn how these genetic changes in cells cause cancer and understand how and why cancer is arising in American Indians in the Southwest. This may help better prevent and treat cancer in the future.

Detailed Description: PRIMARY OBJECTIVES: The overall objective of the PE-CGS Research Center is to develop culturally appropriate, respectful, trusted, and collaborative means to engage and recruit American Indians affected by cancer (newly diagnosed cancer patients, patients undergoing cancer treatment, and cancer survivors) for molecular characterization of their tumors. The clinical trial is embedded in the Patient Engagement Unit (PEU) jointly with the Engagement Optimization Unit (EOU) The specific objectives for the PEU are to: 1. Conduct direct participant engagement with cancer patients/survivors, community advisors, and partners to refine and optimize methods/processes; 2. Identify, recruit and consent eligible AI cancer patients/survivors; 3. Implement tissue acquisition, epidemiologic, behavioral, and clinical data collection, conduct continuous assessment of performance benchmarks; 4. Return clinical grade and clinically useful genomic data to participants with navigation to counseling and clinical resources as warranted and as they select. The specific objectives of the EUO are to: 1. Finalize consenting process and informed consent by direct engagement of AI cancer patients, survivors, healthcare providers, genetic counselors, consenting staff, tribal and spiritual leaders and tribal governance; 2. Determine AI cancer patients' and survivors' knowledge, attitudes, cultural beliefs, information needs, and communication preferences and practices regarding clinical genomics testing; 3. Determine AI cancer patients' and survivors' perspectives on strategies to engage and recruit participants for clinical genomics testing.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States

Contact Details

Name: Cheryl Willman, MD

Affiliation: University of New Mexico Comprehensive Cancer Center

Role: PRINCIPAL_INVESTIGATOR

Name: Ursa Brown-Glaberman, MD

Affiliation: University of New Mexico Comprehensive Cancer Center

Role: STUDY_DIRECTOR

Name: Andrew Sussman, PhD

Affiliation: University of New Mexico Comprehensive Cancer Center

Role: STUDY_DIRECTOR

Name: Shiraz I Mishra, MCCS, PhD

Affiliation: University of New Mexico Comprehensive Cancer Center

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

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