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Brief Title: Study of Intratumoral CV8102 in cMEL, cSCC, hnSCC, and ACC
Official Title: Phase I Study of Intratumoral CV8102 in Patients With Advanced Melanoma, Squamous Cell Carcinoma of the Skin, Squamous Cell Carcinoma of the Head and Neck, or Adenoid Cystic Carcinoma
Study ID: NCT03291002
Brief Summary: This study evaluates intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or adenoid cystic carcinoma. Patients will receive CV8102 as single agent or in combination with SoC anti-PD-1 therapy.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Medical University of Graz, Graz, , Austria
Universitätsklinik fßr Dermatologie der Paracelsus medizinischen Privatuniversität Salzburg, Salzburg, , Austria
HĂ´pital Saint Louis, Paris, , France
Institut Gustave Roussy, Paris, , France
CharitĂŠ Benjamin Franklin, Berlin, , Germany
Medizinische Klinik III, Universitätsklinikum Bonn, Hämatologie, Immunonkologie und Rheumatologie, Bonn, , Germany
Elbe-Klinikum-Buxtehude, Hautkrebszentrum, Buxtehude, , Germany
Universitätsklinikum Erlangen,Hautklinik, Internistisches Zentrum (INZ), Erlangen, , Germany
Nationales Centrum fĂźr Tumorerkrankungen (NCT) Heidelberg, Heidelberg, , Germany
Universitätsklinikum Schleswig-Holstein, Klinik fßr Dermatologie, Allergologie und Venerologie, Lßbeck, , Germany
Fachklinik Hornheide, MĂźnster, , Germany
Universitätsklinikum Mßnster, Klinik fßr Hautkrankheiten, ZiD- Zentrum fßr innovative Dermatologie, Mßnster, , Germany
Universitäts-Hautklinik, Abtl. Dermatologische Onkologie, Tßbingen, , Germany
Center for Personalized Oncology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, , Russian Federation
FSBI "National Medical Research Center of Oncology n.a. N.N. Blokhin" of the Ministry of Healthcare of the Russian Federation, Moscow, , Russian Federation
FSBI "National Medical Research Oncology Center n.a. N.N. Petrov, Saint Petersburg, , Russian Federation
Saint-Petersburg State University, Clinic of advanced medical technologies n. a. Nicolay I. Pirogov., Saint Petersburg, , Russian Federation
Hospital Duran i Reynals - Institut Catala dOncologia ICO, Barcelona, , Spain
Hospital Universitari Vall d'Hebron, Barcelona, , Spain
Hospital Ramon y Cajal, Madrid, , Spain
Hospital Universitario Virgen de la Victoria, MĂĄlaga, , Spain
Hospital Universitario Marqus de Valdecilla Santander, Santander, , Spain
Name: Thomas Eigentler, Prof. Dr.
Affiliation: thomas.eigentler@charite.de
Role: PRINCIPAL_INVESTIGATOR