Neoplasms

All Conditions

Skin and Connective Tissue Diseases

Rare Diseases

Carcinoma

Carcinoma, Squamous Cell

Melanoma

Squamous Cell Carcinoma of Head and Neck

Carcinoma, Adenoid Cystic

Skin Neoplasms

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Neuroendocrine Tumors

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms, Nerve Tissue

Nevus, Pigmented

Nevus

Nevi and Melanomas

Skin Diseases

Neoplasms, Squamous Cell

Head and Neck Neoplasms

Adenocarcinoma

Adenoid Cystic Carcinoma

Neuroendocrine Tumor

Neuroepithelioma

Dose escalation of CV8102 + anti-PD-1 therapy

Optional expansion of CV8102 + anti-PD-1 therapy

CV8102

CV8102 in combination with standard of care anti-PD-1 therapy

CV8102 + anti-PD-1 therapy

Thomas Eigentler, Prof. Dr.

This study evaluates intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or adenoid cystic carcinoma.

Patients will receive CV8102 as single agent or in combination with SoC anti-PD-1 therapy.

Open-label, cohort-based, dose escalation and expansion study

Study of Intratumoral CV8102 in cMEL, cSCC, hnSCC, and ACC

Phase I Study of Intratumoral CV8102 in Patients With Advanced Melanoma, Squamous Cell Carcinoma of the Skin, Squamous Cell Carcinoma of the Head and Neck, or Adenoid Cystic Carcinoma

* Maximum tolerated dose (MTD) and recommended dose (RD), respectively, for CV8102 alone
* MTD and recommended combination dose (RCD) for CV8102 in combination with the standard dose of an anti-PD-1 antagonist

• Tolerability and safety profile of CV8102 alone and in combination with anti-PD-1 antagonists

• Anti-tumor activity of CV8102 per irRECIST and RECIST 1.1

• Extent of tumor response at injected and non-injected lesions, if applicable

Spots Global Cancer Trial Database for cv8102

Every month we try and update this database with for cv8102 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for cv8102

Every month we try and update this database with for cv8102 cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for cv8102 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.