Spots Global Cancer Trial Database for A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.
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Trial Identification
Brief Title: A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.
Official Title: A PHASE 1, OPEN-LABEL, DOSE ESCALATION AND DOSE EXPANSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND ANTI TUMOR ACTIVITY OF PF-07799933 (ARRY-440) AS A SINGLE AGENT AND IN COMBINATION THERAPY IN PARTICIPANTS 16 YEARS AND OLDER WITH ADVANCED SOLID TUMORS WITH BRAF ALTERATIONS
Study ID: NCT05355701
Study Description
Brief Summary: The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07799933) administered as a single agent and in combination with other study medicines (called binimetinib) in people with solid tumors. This study is seeking participants who have an advanced solid tumor with a certain type of abnormal gene called "BRAF" and available treatments are no longer effective in controlling their cancer. All participants in this study will receive PF-07799933. PF-07799933 comes as a tablet to take by mouth, 2 times a day. Depending on the part of the study, participants may also receive another study medicine: * People with melanoma or other solid tumors may also receive binimetinib. Binimetinib comes as a tablet to take by mouth, 2 times a day. * People with colorectal cancer may also receive cetuximab. Cetuximab will be given weekly (or every two weeks) in the clinic as a shot given in the vein or port (intravenous, IV). Participants may receive the study medicines for about 2 years. The study team will monitor how each participant is doing with the study treatment during regular visits at the study clinic.
Detailed Description:
Keywords
Eligibility
Minimum Age: 16 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Highlands Oncology Group, Fayetteville, Arkansas, United States
Highlands Oncology Group, Rogers, Arkansas, United States
Highlands Oncology Group, Springdale, Arkansas, United States
Clinical And Translational Research Center, Aurora, Colorado, United States
UCHealth Sue Anschutz-Rodgers Eye Center, Aurora, Colorado, United States
University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States
University of Colorado Hospital - Anschutz Cancer Pavilion (ACP), Aurora, Colorado, United States
University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP), Aurora, Colorado, United States
University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP), Aurora, Colorado, United States
University of Miami Hospital and Clinics, Sylvester Cancer Center, Miami, Florida, United States
Brigham and Women's Hospital, Boston, Massachusetts, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
DFCI Chestnut Hill, Newton, Massachusetts, United States
Brigitte Harris Cancer Pavilion, Detroit, Michigan, United States
Henry Ford Hospital, Detroit, Michigan, United States
Henry Ford Medical Center - Columbus, Novi, Michigan, United States
MSK Monmouth, Middletown, New Jersey, United States
MSK David H. Koch Center for Cancer Care, New York, New York, United States
Memorial Sloan Kettering Cancer Center 53rd street, New York, New York, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Cleveland Clinic Taussig Cancer Center Investigational Pharmacy, Cleveland, Ohio, United States
Cleveland Clinic Taussing Cancer Center Investigational Pharmacy, Cleveland, Ohio, United States
Cleveland Clinic, Cleveland, Ohio, United States
Providence Cancer Institute Franz Clinic, Portland, Oregon, United States
Providence Portland Medical Center, Portland, Oregon, United States
Sarah Cannon Research Institute - Pharmacy, Nashville, Tennessee, United States
Tennessee Oncology PLLC, Nashville, Tennessee, United States
Tennessee Oncology, PLLC, Nashville, Tennessee, United States
TriStar Bone Marrow Transplant, Nashville, Tennessee, United States
TriStar Centennial Medical Center - Cell Processing Lab, Nashville, Tennessee, United States
TriStar Centennial Medical center, Nashville, Tennessee, United States
South Texas Accelerated Research Therapeutics (START), San Antonio, Texas, United States
Cross Cancer Institute, Edmonton, Alberta, Canada
The Ottawa Hospital - General Campus, Ottawa, Ontario, Canada
Princess Margaret Cancer Centre, Toronto, Ontario, Canada
Jewish General Hospital, Montreal, Quebec, Canada
McGill University Health Centre, Montréal, Quebec, Canada
Rabin Medical Center, Petah Tikva, Hamerkaz, Israel
Sheba Medical Center, Ramat Gan, Hamerkaz, Israel
Sourasky Medical Center, Tel Aviv, Yaffo, Hamerkaz, Israel
Sourasky Medical Center, Tel Aviv, Tell Abīb, Israel
Hadassah Medical Center, Jerusalem, Yerushalayim, Israel
Rambam Health Care Campus, Haifa, Ḥeifā, Israel
Contact Details
Name: Pfizer CT.gov Call Center
Affiliation: Pfizer
Role: STUDY_DIRECTOR
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