Spots Global Cancer Trial Database for AURORA: Aiming to Understand the Molecular Aberrations in Metastatic Breast Cancer.
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Trial Identification
Brief Title: AURORA: Aiming to Understand the Molecular Aberrations in Metastatic Breast Cancer.
Official Title: AURORA: Aiming to Understand the Molecular Aberrations in Metastatic Breast Cancer.
Study ID: NCT02102165
Conditions
Interventions
Study Description
Brief Summary: This program initially aims to recruit 1300 breast cancer patients from a large number of hospitals across Europe. Eligible patients are those who are 18 or older, either female or male, and who have not received more than 1 type of treatment from the time metastases were discovered, metastasi(e)s has just been diagnosed or their disease has come back (disease relapse). Biopsy samples from both the primary and metastatic (or relapsed) tumor will be collected for central analyses, together with blood, serum and plasma samples. Any samples not analyzed immediately will be stored in an independent bio-repository to enable future (not yet defined) research aimed at better understanding metastatic breast cancer. In summary, the main objectives of AURORA are to better understand the genetic aberrations in metastatic breast cancer and to discover the mechanisms of response or resistance to therapy, in order to ultimately identify the "right therapy for each individual patient". At the same time, patients with genetic aberrations that are being targeted by new drugs in development will be offered the possibility to participate in clinical trials, when approved and available in their countries. Ultimately, the aim of AURORA is to improve the outcomes of all patients diagnosed with metastatic breast cancer.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Institut Jules Bordet, Brussels, , Belgium
Cliniques Universitaires St-Luc, Brussels, , Belgium
Grand Hopital Charleroi, Charleroi, , Belgium
UZ Leuven, Leuven, , Belgium
CHU de Liège, Liège, , Belgium
Clinique et Maternité Sainte-Elisabeth (CMSE - Namur), Namur, , Belgium
Kliniken Essen-Mitte, Klinik für Senologie/ Brustzentrum, Essen, , Germany
Frauenkliniken Maistrasse-Innenstadt und Großhadern, München, , Germany
Landspitali, Reykjavík, , Iceland
Ospedale degli Infermi - S.O.C.Oncologia, Biella, , Italy
Ospedale di Bolzano - Oncologia Medica, Bolzano, , Italy
Ospedale Ramazzini di Carpi, Carpi, , Italy
IRCCS AOU San Martino-IST, Genova, , Italy
ULSS 21 Legnago, Legnago, , Italy
Istituto Europeo di Oncologia, Milano, , Italy
UOC Oncologia Medica - AOU Parma, Parma, , Italy
Fondazione Salvatore Maugeri, Pavia, , Italy
IRCCS Az Ospedaliera S.Maria Nuova, Reggio Emilia, , Italy
Centre Hospitalier, Luxembourg, , Luxembourg
Champalimaud Foundation, Lisboa, , Portugal
Complexo Hospitalario Universitario A Coruña, A Coruña, , Spain
Hospital del Mar, Barcelona, , Spain
Dr Rosell Oncology Institute, Quirón Dexeus University Hospital, Barcelona, , Spain
Hospital Vall d'Hebron, Barcelona, , Spain
Consorcio Hospitalario Provincial de Castellón, Castellón De La Plana, , Spain
Hospital San Pedro de Alcantara, Cáceres, , Spain
Hospital Universitari Arnau de Vilanova, Lleida, , Spain
MD Anderson Cancer Center, Madrid, , Spain
Hospital Clínico San Carlos, Madrid, , Spain
Hospital Universitario 12 de Octubre, Madrid, , Spain
Centro Integral Oncológico Clara Campa, Madrid, , Spain
Hospital Universitario Virgen del Rocio, Sevilla, , Spain
Instituto Valenciano de Oncología, Valencia, , Spain
Hospital Clinico Universitario de Valencia, Valencia, , Spain
Hospital General Universitario de Valencia, Valencia, , Spain
Sahlgrenska University Hospital, Gothenburg, , Sweden
Ryhov County Hospital, Jönköping, , Sweden
Kantonsspital Baden, Baden, , Switzerland
Inselspital Bern, Bern, , Switzerland
Kantonsspital Graubuenden, Chur, , Switzerland
Luzerner Kantonsspital, Division of Medical Oncology, Lucerne, , Switzerland
Queen Elizabeth Hospital - University Hospitals Birmingham NHS Foundation Trust, Birmingham, , United Kingdom
University Hospitals Bristol NHS Foundation Trust, Bristol, , United Kingdom
Velindre NHS Trust, Cardiff, , United Kingdom
NHS Tayside, Ninewells Hospital, Dundee, , United Kingdom
Edinburgh Cancer Centre - Western General Hospital, Edinburgh, , United Kingdom
Beatson West of Scotland Cancer Centre, Glasgow, , United Kingdom
Christie NHS Foundation Trust, Manchester, , United Kingdom
Nottingham University Hospital NHS Trust, Nottingham, , United Kingdom
Singleton Hospital - ABM University Health Board, Swansea, , United Kingdom
Royal Cornwall Hospital - Royal Cornwall Hospitals NHS Trust, Truro, , United Kingdom
Yeovil District Hospital NHS Foundation Trust, Yeovil, , United Kingdom
Contact Details
Name: Philippe Aftimos, MD
Affiliation: Institut Jules Bordet, Brussels, Belgium
Role: PRINCIPAL_INVESTIGATOR
Name: Angel Guerrero Zotano, MD
Affiliation: Instituto Valenciano de Oncologia, Valencia, Spain
Role: PRINCIPAL_INVESTIGATOR
Name: Matteo Benelli, PhD
Affiliation: Breast International Group
Role: PRINCIPAL_INVESTIGATOR
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