Spots Global Cancer Trial Database for Clinical Application of Circulating Tumor DNA (ctDNA) in Patients With Late-stage Breast Cancer
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Trial Identification
Brief Title: Clinical Application of Circulating Tumor DNA (ctDNA) in Patients With Late-stage Breast Cancer
Official Title: Clinical Application of Circulating Tumor DNA (ctDNA) to Monitor the Molecular Tumor Burden in Patients With Late-stage Breast Cancer
Study ID: NCT05079074
Interventions
Study Description
Brief Summary: This is a retrospective, observational, multi-center clinical study of circulating tumor DNA (ctDNA) application in late-stage breast cancers.
Detailed Description: This study aims to evaluate the feasibility of plasma ctDNA mutation spectrum and clonal spectrum in late-stage metastatic breast cancer patients. Meanwhile, this study tries to establish a model of ctDNA subtyping system to evaluate the molecular load of tumor, to evaluate the curative effect comprehensively and to detect the disease progression in advance. In addition, the investigators plan to explore the clonal evolution of ctDNA in patients with progressive disease (PD), and to monitor the changes of tumor heterogeneity from the molecular level, so as to provide reference for the analysis of drug sensitivity.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
Contact Details
Name: Quchang Ouyang, MD
Affiliation: Hunan Cancer Hospital
Role: PRINCIPAL_INVESTIGATOR
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