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Brief Title: Stereotactic Radiotherapy for Oligo-Progressive Metastatic Cancer (The STOP Trial)
Official Title: Stereotactic Radiotherapy for Oligo-Progressive Metastatic Cancer (The STOP Trial): A Randomized Phase II Trial
Study ID: NCT02756793
Brief Summary: A multicenter randomized phase II trial of stereotactic body radiotherapy for oligo-progressive metastatic cancers. Eligible patients will be randomized in a 1:2 ratio between receiving their standard of care therapy or stereotactic ablative radiotherapy (SABR) to all sites of oligo-progressive lesions.Radiotherapy will be administered as soon as possible following randomization, and subjects will be followed until next disease progression. The primary outcome is progression-free survival (PFS).
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Alberta Health Services-Cross Cancer Institute, Edmonton, Alberta, Canada
BC Cancer - Prince George, Prince George, British Columbia, Canada
BC Cancer Fraser Valley Centre, Surrey, British Columbia, Canada
BC Cancer Agency Branch, Vancouver, British Columbia, Canada
BC Cancer - Victoria Centre, Victoria, British Columbia, Canada
London Regional Cancer Program, London, Ontario, Canada
Princess Margaret Cancer Centre, Toronto, Ontario, Canada