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Brief Title: Study to Evaluate CCS1477 in Advanced Tumours
Official Title: An Open-label Phase I/IIa Study to Evaluate the Safety and Efficacy of CCS1477 as Monotherapy and in Combination, in Patients With Advanced Solid/Metastatic Tumours.
Study ID: NCT03568656
Brief Summary: A Phase 1/2a study to assess the safety, tolerability, PK and biological activity of CCS1477 in patients with metastatic castration resistant prostate cancer, metastatic breast cancer, non-small cell lung cancer or advanced solid tumours.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York, United States
Thomas Jefferson University, Sidney Kimmel Cancer Center, Philadelphia, Pennsylvania, United States
Institute Bergonie, Bordeaux, , France
Hôpital Europeen Georges Pompidou, Paris, , France
Institute Gustave Roussy, Villejuif, , France
Netherlands Cancer Institute (NKI), Amsterdam, , Netherlands
Erasmus MC Institute, Rotterdam, , Netherlands
Hospital Vall d'Hebron, VHIO, Barcelona, , Spain
START CIOCC Hospital Universitario HM, Madrid, , Spain
INCLIVA Biomedical Research Institute, Valencia, , Spain
Karolinska Institute, Stockholm, , Sweden
Belfast City Hospital, Belfast, , United Kingdom
Queen Elizabeth Hospital Cancer Centre, Birmingham, , United Kingdom
Cambridge University Hospital, Cambridge, , United Kingdom
Edinburgh Cancer Centre Western General Hospital, Edinburgh, , United Kingdom
The Beatson West of Scotland Cancer Centre, Glasgow, , United Kingdom
Leicester Royal Infirmary, Leicester, , United Kingdom
The Christie Hospital, Manchester, , United Kingdom
Freeman Hospital, Newcastle, , United Kingdom
University Hospital Southampton, Southampton, , United Kingdom
Royal Marsden Hospital, Sutton, , United Kingdom
Name: Johann de Bono, MD
Affiliation: Royal Marsden NHS Foundation Trust
Role: PRINCIPAL_INVESTIGATOR