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Brief Title: ZN-c3 in Adult Participants With Metastatic Colorectal Cancer
Official Title: A Phase 1/2, Open-Label, Multi-Center Study of ZN-c3 Administered in Combination With Encorafenib and Cetuximab in Adults With Metastatic Colorectal Cancer
Study ID: NCT05743036
Brief Summary: The purpose of this study is to evaluate the safety, tolerability, and potential clinical benefits of ZN-c3 administered in combination with encorafenib and cetuximab in adult participants with metastatic BRAF V600E mutant colorectal cancer previously treated with one or two treatment regimens.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
USC Norris Comprehensive Cancer Center, Los Angeles, California, United States
Alliance for Multispecialty Research, LLC, Merriam, Kansas, United States
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
The Queen Elizabeth Hospital, Woodville South, South Australia, Australia
Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Hämatologie- Onkologie im Zentrum MVZ GmbH, Augsburg, Bayern, Germany
Klinikum der Universität München Großhadern, Muenchen, Bayern, Germany
Muenchen Klinik Neuperlach, Klinik fuer Haematologie und Onkologie, Muenchen, Bayern, Germany
Institut für Klinisch Onkologische Forschung, Frankfurt, Hessen, Germany
DRK Kliniken Berlin - Köpenick, Berlin, , Germany
Semmelweis University-Department of Internal Medicine and Oncology, Budapest, , Hungary
Clinexpert Kft. Bugat Pal Korhaz, Gyöngyös, , Hungary
Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Campania, Italy
IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
AOUI Verona, Verona, Veneto, Italy
Istituto Europeo di Oncologia, Milano, , Italy
ASST Grande Ospedale Metropolitano Niguarda, Milano, , Italy
Szpital Uniwersytecki w Krakowie, Kraków, Malopolskie, Poland
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie, Kraków, Malopolskie, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie, Warsaw, Mazowieckie, Poland
Opolskie Centrum Onkologii w Opolu im. prof. Tadeusza Koszarowskiego, Opole, Opolskie, Poland
Parc de Salut Mar - Hospital del Mar, Barcelona, Cataluna, Spain
Hospital Universitario Reina Sofia, Córdoba, Cordoba, Spain
Fundación Instituto Valenciano de Oncología, Valencia, Valenciana, Comunitat, Spain
Hospital Universitari Vall d'Hebron, Barcelona, , Spain
Hospital Universitario La Paz, Madrid, , Spain
Hospital Universitario Puerta de Hierro Majadahonda, Madrid, , Spain