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Brief Title: ASPECCT: A Study of Panitumumab Efficacy and Safety Compared to Cetuximab in Patients With KRAS Wild-Type Metastatic Colorectal Cancer
Official Title: A Randomized, Multicenter, Open-label, Phase 3 Study to Compare the Efficacy and Safety of Panitumumab and Cetuximab in Subjects With Previously Treated, Wild-type KRAS, Metastatic Colorectal Cancer
Study ID: NCT01001377
Brief Summary: The primary objective of this study is to compare the effect of panitumumab versus cetuximab on overall survival (OS) for chemorefractory metastatic colorectal cancer (mCRC) among patients with wild-type Kirsten rat Sarcoma-2 virus (KRAS) tumors.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Research Site, Stockton, California, United States
Research Site, Boynton Beach, Florida, United States
Research Site, Wichita, Kansas, United States
Research Site, Temple, Texas, United States
Research Site, Ogden, Utah, United States
Research Site, Liverpool, New South Wales, Australia
Research Site, St Leonards, New South Wales, Australia
Research Site, Wahroonga, New South Wales, Australia
Research Site, Wollongong, New South Wales, Australia
Research Site, Woodville South, South Australia, Australia
Research Site, Ballarat, Victoria, Australia
Research Site, Box Hill, Victoria, Australia
Research Site, Epping, Victoria, Australia
Research Site, Footscray, Victoria, Australia
Research Site, Heidelberg, Victoria, Australia
Research Site, Parkville, Victoria, Australia
Research Site, Edegem, , Belgium
Research Site, Sofia, , Bulgaria
Research Site, Sofia, , Bulgaria
Research Site, Edmonton, Alberta, Canada
Research Site, Halifax, Nova Scotia, Canada
Research Site, Guangzhou, Guangdong, China
Research Site, Guangzhou, Guangdong, China
Research Site, Guangzhou, Guangdong, China
Research Site, Guangzhou, Guangdong, China
Research Site, Harbin, Heilongjiang, China
Research Site, Changsha, Hunan, China
Research Site, Nanjing, Jiangsu, China
Research Site, Changchun, Jilin, China
Research Site, XI An, Shaanxi, China
Research Site, Shanghai, Shanghai, China
Research Site, Chengdu, Sichuan, China
Research Site, Chongqing, Sichuan, China
Research Site, Hangzhou, Zhejiang, China
Research Site, Hangzhou, Zhejiang, China
Research Site, Beijing, , China
Research Site, Beijing, , China
Research Site, Beijing, , China
Research Site, Shanghai, , China
Research Site, Shanghai, , China
Research Site, Shanghai, , China
Research Site, Tianjin, , China
Research Site, Horovice, , Czechia
Research Site, Nova Ves pod Plesi, , Czechia
Research Site, Olomouc, , Czechia
Research Site, Praha 10, , Czechia
Research Site, Pribram, , Czechia
Research Site, Znojmo, , Czechia
Research Site, Besançon Cedex, , France
Research Site, Montbéliard, , France
Research Site, Saint Brieuc, , France
Research Site, Saint Herblain, , France
Research Site, Villejuif cedex, , France
Research Site, Kowloon, , Hong Kong
Research Site, New Territories, , Hong Kong
Research Site, Hyderabad, Andhra Pradesh, India
Research Site, Hyderabad, Andhra Pradesh, India
Research Site, Kochi, Kerala, India
Research Site, Ahmednagar, Maharashtra, India
Research Site, Nagpur, Maharashtra, India
Research Site, Nashik, Maharashtra, India
Research Site, Nashik, Maharashtra, India
Research Site, Pune, Maharashtra, India
Research Site, Jaipur, Rajasthan, India
Research Site, Chennai, Tamil Nadu, India
Research Site, Kolkata, West Bengal, India
Research Site, Beer Sheva, , Israel
Research Site, Jerusalem, , Israel
Research Site, Kfar Saba, , Israel
Research Site, Ramat Gan, , Israel
Research Site, Rehovot, , Israel
Research Site, Ancona, , Italy
Research Site, Cesena, , Italy
Research Site, Cremona, , Italy
Research Site, Faenza RA, , Italy
Research Site, Genova, , Italy
Research Site, Lugo, , Italy
Research Site, Meldola FC, , Italy
Research Site, Ravenna, , Italy
Research Site, Rimini, , Italy
Research Site, Torino, , Italy
Research Site, Goyang-si, Gyeonggi-do, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Daugavpils, , Latvia
Research Site, Riga, , Latvia
Research Site, Riga, , Latvia
Research Site, Kaunas, , Lithuania
Research Site, Vilnius, , Lithuania
Research Site, Kota Bharu, Kelantan, Malaysia
Research Site, Kota Kinabalu, Sabah, Malaysia
Research Site, Kuala Lumpur, Wilayah Persekutuan, Malaysia
Research Site, Kuala Lumpur, Wilayah Persekutuan, Malaysia
Research Site, Rotterdam, , Netherlands
Research Site, Lima, , Peru
Research Site, Lima, , Peru
Research Site, Lima, , Peru
Research Site, Cebu City, , Philippines
Research Site, Manila, , Philippines
Research Site, Quezon City, , Philippines
Research Site, Elblag, , Poland
Research Site, Gdansk, , Poland
Research Site, Jelenia Gora, , Poland
Research Site, Poznan, , Poland
Research Site, Szczecin, , Poland
Research Site, Warszawa, , Poland
Research Site, Warszawa, , Poland
Research Site, Warszawa, , Poland
Research Site, Bucharest, , Romania
Research Site, Sibiu, , Romania
Research Site, Moscow, , Russian Federation
Research Site, Moscow, , Russian Federation
Research Site, Saint Petersburg, , Russian Federation
Research Site, Saint-Petersburg, , Russian Federation
Research Site, Saint-Petersburg, , Russian Federation
Research Site, Nis, , Serbia
Research Site, Sremska Kamenica, , Serbia
Research Site, Singapore, , Singapore
Research Site, Singapore, , Singapore
Research Site, Bardejov, , Slovakia
Research Site, Bratislava, , Slovakia
Research Site, Nitra, , Slovakia
Research Site, Groenkloof, Gauteng, South Africa
Research Site, Johannesburg, Gauteng, South Africa
Research Site, Kraaifontein, Western Cape, South Africa
Research Site, Johannesburg, , South Africa
Research Site, Port Elizabeth, , South Africa
Research Site, Göteborg, , Sweden
Research Site, Linköping, , Sweden
Research Site, Lund, , Sweden
Research Site, Uppsala, , Sweden
Research Site, Västerås, , Sweden
Research Site, Växjö, , Sweden
Research Site, Putzu City, Chiayi, Taiwan
Research Site, Keelung, , Taiwan
Research Site, Tainan, , Taiwan
Research Site, Taipei, , Taiwan
Research Site, Taoyuan, , Taiwan
Research Site, Belfast, , United Kingdom
Research Site, Bristol, , United Kingdom
Research Site, Cardiff, , United Kingdom
Research Site, Guildford, , United Kingdom
Research Site, Leicester, , United Kingdom
Research Site, London, , United Kingdom
Research Site, Maidstone, , United Kingdom
Research Site, Manchester, , United Kingdom
Research Site, Oxford, , United Kingdom
Research Site, Sutton, , United Kingdom
Research Site, Wolverhampton, , United Kingdom
Name: MD
Affiliation: Amgen
Role: STUDY_DIRECTOR