Spots Global Cancer Trial Database for MUTYH-associated Polyposis

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Trial Identification

Brief Title: MUTYH-associated Polyposis

Official Title: Diagnosis and Treatment of Russian Patients With MutYH-associated Polyposis

Study ID: NCT03847532

Conditions

MutYH-associated Polyposis

Interventions

Sanger sequencing method

Study Description

Brief Summary: This is single-center, prospective, non-randomized study

Detailed Description: The study will include patients with more than 3 polyps, without mutations in the APC gene. Using molecular genetic research methods (polymerase chain reaction, SSCP, sequencing by Sanger method) mutations in the MutYH gene will be studied. For all patients with mutations in the MutYH gene, an optimal diagnostic algorithm will be developed. The significance of monoallelic mutations in the MutYH gene will be determined. Clinical monitoring will be defined. Optimal amount of surgical intervention will be suggested.