Spots Global Cancer Trial Database for 18F-FMISO PET Guided Dose Escalation in Nasopharyngeal Carcinoma - a Feasibility and Planning Study

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Trial Identification

Brief Title: 18F-FMISO PET Guided Dose Escalation in Nasopharyngeal Carcinoma - a Feasibility and Planning Study

Official Title: 18F-FMISO PET Guided Dose Escalation in Nasopharyngeal Carcinoma - a Feasibility and Planning Study

Study ID: NCT04995185

Conditions

Nasopharyngeal Carcinoma

Interventions

(18)F-fluoromisonidazole (FMISO)

Study Description

Brief Summary: This study aims to investigate the use of 18F-FMISO PET in identifying hypoxic subvolume for dose escalation radiotherapy in nasopharyngeal cancer and thus improve local control without significant increase in toxicities.

Detailed Description: The specific aims of this study are: 1. To establish hypoxia imaging in NPC patients 2. Investigate the dynamics of tumor hypoxia before and during chemoradiation 3. Integrate hypoxia imaging into radiation treatment planning protocols 4. Design hypoxia adapted radiation schedules 5. Identify candidate hypoxia biomarkers