Spots Global Cancer Trial Database for hypoxia
Every month we try and update this database with for hypoxia cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| qBOLD MRI of Glioblastoma Multiforme for Assessment of Tumor Hypoxia. | NCT02466828 | Glioblastoma Hypoxia | Feraheme® | 18 Years - | Sunnybrook Health Sciences Centre | |
| 18F-FMISO PET Guided Dose Escalation in Nasopharyngeal Carcinoma - a Feasibility and Planning Study | NCT04995185 | Nasopharyngeal ... | (18)F-fluoromis... | 21 Years - 99 Years | National Cancer Centre, Singapore | |
| High-flow Nasal Cannula Oxygenation Decrease Hypoxia in Sedated Gastrointestinal Endoscopes in Obesity | NCT04500392 | Hypoxia Gastric Cancer Esophagus Cance... Polyp of Colon Colon Cancer | High-flow nasal... Regular nasal c... | 18 Years - 70 Years | RenJi Hospital | |
| Multimodal Imaging of Hypoxia in Gliomas | NCT03716986 | Glioma | MRI Oxygen Satu... | 18 Years - | University Hospital, Caen | |
| One Time Injection of Bacteria to Treat Solid Tumors That Have Not Responded to Standard Therapy | NCT00358397 | Tumors | Clostridium nov... | 18 Years - | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | |
| Biomarkers for Clinical Hypoxia Evaluation in Cervical Cancer | NCT05029258 | Cervical Cancer | Biopsy of tumou... MRI scans | 18 Years - | University of Manchester | |
| De-escalation of Radiation Dose in HPV-associated OPC Utilising FMISO PET (DE-RADIATE) | NCT06307015 | HPV Positive Or... | De-escalation Standard of car... | 18 Years - | Royal North Shore Hospital | |
| De-escalation of Radiation Dose in HPV-associated OPC Utilising FMISO PET (DE-RADIATE) | NCT06307015 | HPV Positive Or... | De-escalation Standard of car... | 18 Years - | Royal North Shore Hospital | |
| The Gene Expression Studies of the Role of Tumor Microenvironments in Tumor Progression | NCT00638040 | Hypoxia Lactic Acidosis | 18 Years - 50 Years | Duke University | ||
| Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer | NCT02174549 | Hepatocellular ... Gastrointestina... Neuroendocrine ... | Tirapazamine Conventional Tr... | 20 Years - 99 Years | Teclison Ltd. | |
| A Phase I Study of the Safety, Pharmacokinetics, and Anti-Tumor Activity of TH-302 in Patients With Advanced Solid Tumors | NCT00495144 | Tumors Hypoxia | TH-302 | 18 Years - | Threshold Pharmaceuticals | |
| Study for Treatment of Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck or Skin | NCT02449681 | Metastatic Head... | TH-4000 (Tarlox... | 18 Years - | Rain Oncology Inc | |
| Chemotherapy for Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma | NCT00090727 | Solid Malignanc... Non-Hodgkin's L... | AQ4N | 18 Years - | Novacea | |
| Predictive Assays In Cervix Cancer | NCT01181375 | Cervical Cancer | Tumour Biopsies... | 18 Years - | University Health Network, Toronto | |
| Exercise for Improving Prostate Oxygenation in Prostate Tumors (Exipox) | NCT03365076 | Prostate Cancer Physical Activi... Hypoxia | Physical activi... | 18 Years - | University Hospital of North Norway | |
| An Exploratory, Open Label, Multi-Center, Non-Randomized Study of [F-18]VM4-037 | NCT00884520 | Lung Cancer Squamous Cell C... Head and Neck C... Hepatic Carcino... Renal Cell Carc... | [F-18] VM4-037 | 18 Years - | Siemens Molecular Imaging | |
| Ultrafiltration (Aquapheresis) in Patients With Leukemia and Severe Fluid Overload | NCT01508260 | Leukemia | Aquapheresis Furosemide | 18 Years - | M.D. Anderson Cancer Center | |
| Investigation of Hemoglobin Oxygenation With Third Harmonic Generation Microscopy | NCT03619356 | Hypoxia Oxygen Deficien... Tumor Diabetes | 20 Years - | National Taiwan University Hospital | ||
| Nitroglycerin Plus Intracranial Radiotherapy for Brain Metastases in NSCLC Patients | NCT04338867 | Phase II Clinic... Ninety-six Hist... Randomized 1:1 ... ICPFS Evaluated... | Whole-brain rad... | 18 Years - 90 Years | Instituto Nacional de Cancerologia de Mexico | |
| Biomarkers for Clinical Hypoxia Evaluation in Cervical Cancer | NCT05029258 | Cervical Cancer | Biopsy of tumou... MRI scans | 18 Years - | University of Manchester | |
| RHYTHM-I: Investigating Hypoxia in Rectal Tumours | NCT02157246 | Hypoxia in Rect... | Pimonidazole F-MISO PET pCT Functional MRI Biopsy Blood sample | 18 Years - | University of Oxford | |
| FAZA PET/MRI Sarcoma | NCT03418818 | Sarcoma | 18F-FAZA Pimonidazole | 18 Years - | University Health Network, Toronto | |
| Safety Study of Intratumoral Injection of Clostridium Novyi-NT Spores to Treat Patients With Solid Tumors That Have Not Responded to Standard Therapies | NCT01924689 | Solid Tumor Mal... | Clostridium nov... | 18 Years - | BioMed Valley Discoveries, Inc | |
| Capnographic Monitoring in Gastrointestinal Endoscopy for Elderly Patients | NCT05030870 | Hypoxia Gastric Cancer Gastric Polyp Colon Polyp Colon Cancer Esophageal Canc... | Capnography mon... Standard monito... | 65 Years - 79 Years | RenJi Hospital | |
| Autophagy Inhibition Using Hydrochloroquine in Breast Cancer Patients | NCT01292408 | Breast Cancer | Hydrochloroquin... | - | Radboud University Medical Center | |
| Oxygen Measurements in Subcutaneous Tumors by EPR Oximetry Using OxyChip | NCT02706197 | Neoplasms, Beni... Neoplasms, Mali... | OxyChip | 18 Years - | Dartmouth-Hitchcock Medical Center | |
| Integrated Clinical-radiological Analysis of Hypoxia Markers in Pediatric Osteosarcomas | NCT05107843 | Osteosarcoma in... | 1 Year - 20 Years | University Hospital, Strasbourg, France | ||
| Capnographic Monitoring in Gastrointestinal Endoscopy for Elderly Patients | NCT05030870 | Hypoxia Gastric Cancer Gastric Polyp Colon Polyp Colon Cancer Esophageal Canc... | Capnography mon... Standard monito... | 65 Years - 79 Years | RenJi Hospital | |
| Hypoxia Analysis in Head and/or Neck Cancer | NCT02414048 | Head and Neck C... | Pimonidazole | 18 Years - | University of Zurich | |
| Study for Treatment of Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck or Skin | NCT02449681 | Metastatic Head... | TH-4000 (Tarlox... | 18 Years - | Rain Oncology Inc | |
| A Study of Hypoxia Imaging in Advanced Pancreatic Cancer Patients Being Treated With Gemcitabine and TH-302 or TH-302 Placebo | NCT02496832 | Pancreatic Aden... Advanced Diseas... Metastatic Dise... | 18F-Fluoroazomy... | 18 Years - | University Health Network, Toronto | |
| The Gene Expression Studies of the Role of Tumor Microenvironments in Tumor Progression | NCT00638040 | Hypoxia Lactic Acidosis | 18 Years - 50 Years | Duke University | ||
| In Vivo Assessment of Hypoxia in Gastro-intestinal Cancer Using 18F-HX4-PET: an Optimization and Reproducibility Study | NCT01995084 | Pancreatic Canc... Esophageal Canc... Rectal Cancer | [F-18]HX4 | 18 Years - | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | |
| Multimodal Imaging of Hypoxia in Gliomas | NCT03716986 | Glioma | MRI Oxygen Satu... | 18 Years - | University Hospital, Caen | |
| PET With [18F]HX4 in Head and Neck Cancer | NCT01347281 | Cancer of the H... | Injection of [1... | 18 Years - 100 Years | Maastricht Radiation Oncology | |
| Immunotherapy Study of Evofosfamide in Combination With Ipilimumab | NCT03098160 | Pancreatic Canc... Melanoma Squamous Cell C... Prostate Cancer | Evofosfamide Ipilimumab | 18 Years - | Threshold Pharmaceuticals | |
| Low-Flow vs. High-Flow Nasal Cannula for Hypoxemic Immunocompromised Patients During Diagnostic Bronchoscopy | NCT03168815 | Immunocompromis... Hematologic Mal... Post Hematopoie... Hypoxia Pulmonary Infil... | High Flow Nasal... | 18 Years - | Mount Sinai Hospital, Canada | |
| Tumor Hypoxia With HX4 PET in Several Diseases | NCT02584400 | Prostatic Neopl... Esophageal Neop... Neoplasm Metast... Rectal Neoplasm... Brain Neoplasm,... | Injection with ... | 18 Years - | Maastricht Radiation Oncology | |
| HFNO Combined With NPA Reduces Hypoxia During Sedated Gastrointestinal Endoscopy In Obese Patients | NCT05526339 | Gastric Cancer Gastric Ulcer Intestinal Canc... Intestinal Poly... | High-flow nasal... Regular nasal c... | 19 Years - 80 Years | RenJi Hospital | |
| FMISO-based Adaptive Radiotherapy for Head and Neck Cancer | NCT05348486 | Head and Neck C... Hypoxia FMISO Dose Escalation | Dose escalation | 18 Years - | University Hospital Olomouc | |
| Safety Study of Intratumoral Injection of Clostridium Novyi-NT Spores to Treat Patients With Solid Tumors That Have Not Responded to Standard Therapies | NCT01924689 | Solid Tumor Mal... | Clostridium nov... | 18 Years - | BioMed Valley Discoveries, Inc | |
| Predictive Assays In Cervix Cancer | NCT01181375 | Cervical Cancer | Tumour Biopsies... | 18 Years - | University Health Network, Toronto | |
| Impact of Selective Radiation Dose Escalation and Tumour Hypoxia Status on Locoregional Tumour Control After Radiochemotherapy of HNT | NCT01212354 | Locally Advance... | Radiotherapy | 18 Years - 70 Years | Technical University of Munich | |
| Clinical Evaluation of the New Hypoxia Imaging Agent HX4 | NCT01213030 | Head and Neck C... Lung Cancer Liver Cancer | [F-18] FMISO [F-18] HX4 | 18 Years - | Siemens Molecular Imaging | |
| DAHANCA 30: A Randomized Non-inferiority Trial of Hypoxia-profile Guided Hypoxic Modification of Radiotherapy of HNSCC. | NCT02661152 | Head and Neck S... Radiotherapy Hypoxic Modific... Hypoxia Gene Profile, G... | Nimorazole | 18 Years - | Danish Head and Neck Cancer Group | |
| Nitroglycerin in Non-small Cell Lung Cancer | NCT01210378 | Non Small Cell ... | Nitroglycerin p... | 18 Years - | Maastricht Radiation Oncology | |
| Evaluation of [18F]-FMISO for Non Operated Glioblastoma | NCT00906893 | Glioblastoma | 18F]-FMISO PET-... | 18 Years - | University Hospital, Bordeaux | |
| HFNO Combined With NPA Reduces Hypoxia During Sedated Gastrointestinal Endoscopy In Obese Patients | NCT05526339 | Gastric Cancer Gastric Ulcer Intestinal Canc... Intestinal Poly... | High-flow nasal... Regular nasal c... | 19 Years - 80 Years | RenJi Hospital | |
| Moderate Whole Body Hyperthermia for Patients Undergoing Re-irradiation for Head and Neck Cancer -Influence on the Tumor Microenvironment | NCT03547388 | Head and Neck N... Recurrence Tumo... | Moderate whole ... | 18 Years - 75 Years | Charite University, Berlin, Germany | |
| Atovaquone as Tumour HypOxia Modifier | NCT02628080 | Carcinoma, Non-... | Atovaquone | 18 Years - | University of Oxford | |
| HFNO Combined With NPA Reduces Hypoxia During Sedated Gastrointestinal Endoscopy In Obese Patients | NCT05526339 | Gastric Cancer Gastric Ulcer Intestinal Canc... Intestinal Poly... | High-flow nasal... Regular nasal c... | 19 Years - 80 Years | RenJi Hospital | |
| Study of Intratumoral Hypoxia Using Pre-operative Administration of Pimonidazole | NCT01248637 | Pancreatic Canc... | Pimonidazole hy... | 18 Years - | University Health Network, Toronto | |
| Validation of 18F-MISO-PET and 18F-FLT-PET | NCT00159978 | Head and Neck N... | 18F-FLT and 18F... | 18 Years - | Radboud University Medical Center | |
| Nitroglycerin Plus Intracranial Radiotherapy for Brain Metastases in NSCLC Patients | NCT04338867 | Phase II Clinic... Ninety-six Hist... Randomized 1:1 ... ICPFS Evaluated... | Whole-brain rad... | 18 Years - 90 Years | Instituto Nacional de Cancerologia de Mexico | |
| Evaluation of Hypoxia by PET With F-Miso in Radiation Therapy of Prostate Cancer | NCT01898065 | Prostate Adenoc... | 18-F-MISO | 18 Years - | Institut Cancerologie de l'Ouest | |
| Impact of Selective Radiation Dose Escalation and Tumour Hypoxia Status on Locoregional Tumour Control After Radiochemotherapy of HNT | NCT01212354 | Locally Advance... | Radiotherapy | 18 Years - 70 Years | Technical University of Munich | |
| Evaluation of Hypoxia by PET With F-Miso in Radiation Therapy of Prostate Cancer | NCT01898065 | Prostate Adenoc... | 18-F-MISO | 18 Years - | Institut Cancerologie de l'Ouest | |
| FMISO-based Adaptive Radiotherapy for Head and Neck Cancer | NCT05348486 | Head and Neck C... Hypoxia FMISO Dose Escalation | Dose escalation | 18 Years - | University Hospital Olomouc | |
| Prophylactic Irradiation of the Para-Aortic Lymph Nodes in Locally Advanced Uterine Cervical Cancer | NCT00980759 | Cervical Cancer | EFI Pelvic RT | 18 Years - 80 Years | National Cancer Center, Korea | |
| Nasal Mask Kit in Gastrointestinal Endoscopy | NCT05405530 | Hypoxia Gastric Cancer Gastric Polyp Colon Polyp Colon Cancer Esophageal Canc... | nasal mask oxyg... regular nasal c... | 18 Years - 60 Years | RenJi Hospital | |
| FAZA PET/MRI Pancreas | NCT04395469 | Pancreatic Aden... Locally Advance... Unresectable Pa... | 18F-FAZA | 18 Years - | University Health Network, Toronto | |
| PET With [18F]HX4 in Head and Neck Cancer | NCT01347281 | Cancer of the H... | Injection of [1... | 18 Years - 100 Years | Maastricht Radiation Oncology | |
| Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer | NCT02174549 | Hepatocellular ... Gastrointestina... Neuroendocrine ... | Tirapazamine Conventional Tr... | 20 Years - 99 Years | Teclison Ltd. | |
| High-flow Nasal Cannula Oxygenation Decrease Hypoxia in Sedated Gastrointestinal Endoscopes in Obesity | NCT04500392 | Hypoxia Gastric Cancer Esophagus Cance... Polyp of Colon Colon Cancer | High-flow nasal... Regular nasal c... | 18 Years - 70 Years | RenJi Hospital | |
| Assessing the Relationship Between Hypoxia and the Immune Environment in Myeloma Patients (CHIME) | NCT06007989 | Myeloma | 18 Years - | The Christie NHS Foundation Trust | ||
| Effects of OXY111A in Primary and Secondary Hepato-Pancreato-Biliary Neoplasm | NCT02528526 | Pancreatic Neop... Hepatocellular ... Cholangiocarcin... Colorectal Neop... | OXY111A | 18 Years - | University of Zurich | |
| Integrated Clinical-radiological Analysis of Hypoxia Markers in Pediatric Osteosarcomas | NCT05107843 | Osteosarcoma in... | 1 Year - 20 Years | University Hospital, Strasbourg, France | ||
| Palliative Thoracic Radiotherapy Plus BKM120 | NCT02128724 | Carcinoma, Non-... | BKM120 | 18 Years - | University of Oxford | |
| Atovaquone as Tumour HypOxia Modifier | NCT02628080 | Carcinoma, Non-... | Atovaquone | 18 Years - | University of Oxford | |
| The Role of the Tumor Microenvironment of Pancreatic Cancer to Predict Treatment Outcome | NCT01989000 | Pancreatic Canc... | Gadobutrol [F-18]HX4 Gemcitabine Radiotherapy Pancreaticoduod... | 18 Years - | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | |
| A Study Using 18F-FAZA and PET Scans to Study Hypoxia in Pancreatic Cancer | NCT01542177 | Pancreatic Canc... Hypoxia | 18 Years - | University Health Network, Toronto | ||
| Study for Treatment With TH-4000 (Tarloxotinib) in Epidermal Growth Factor Receptor (EGFR) Mutant, T790M-negative Non-small Cell Lung Cancer (NSCLC) Patients | NCT02454842 | Non-small Cell ... NSCLC Non-squamous NS... | TH-4000 (Tarlox... | 18 Years - | Rain Oncology Inc | |
| HFNO Reduces Hypoxia During Sedated Gastroscopy or Colonoscopy in High Risk Patients | NCT05510388 | Gastric Cancer Intestinal Canc... Intestine Adeno... Gastritis | High-flow nasal... Regular nasal c... | 18 Years - 80 Years | RenJi Hospital | |
| Pathological Validation of Functional Imaging in Head and Neck Squamous Cell Carcinoma | NCT01827709 | Head and Neck C... | A polymerase ch... Functional imag... Immunohistochem... MRI of the rese... Tumour volume d... | 18 Years - | Universitaire Ziekenhuizen KU Leuven | |
| Efficacy and Safety of Remimazolam Tosylate for Sedation in Gastroscopy | NCT04727034 | Hypoxia Gastric Cancer Sedation Compli... Propofol Advers... | Remimazolam tos... Propofol | 18 Years - 60 Years | RenJi Hospital | |
| RHYTHM-I: Investigating Hypoxia in Rectal Tumours | NCT02157246 | Hypoxia in Rect... | Pimonidazole F-MISO PET pCT Functional MRI Biopsy Blood sample | 18 Years - | University of Oxford | |
| Safety Study of Clostridium Novyi-NT Spores to Treat Patients With Solid Tumors That Have Not Responded to Standard Therapies | NCT01118819 | Solid Tumor Mal... | Clostridium nov... | 18 Years - | BioMed Valley Discoveries, Inc | |
| Assessing the Relationship Between Hypoxia and the Immune Environment in Myeloma Patients (CHIME) | NCT06007989 | Myeloma | 18 Years - | The Christie NHS Foundation Trust | ||
| WEI NASAL JET for The Sedation of Outpatient Upper Gastrointestinal Endoscopy | NCT02436018 | Peptic Ulcer Gastric Cancer Esophagus Cance... Oesophagitis Hypoxia | WEI NASAL JET Nasopharyngeal ... | 18 Years - | RenJi Hospital | |
| A Phase I Study of the Safety, Pharmacokinetics, and Anti-Tumor Activity of TH-302 in Patients With Advanced Solid Tumors | NCT00495144 | Tumors Hypoxia | TH-302 | 18 Years - | Threshold Pharmaceuticals |
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