Spots Global Cancer Trial Database for Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma (NPC)
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Trial Identification
Brief Title: Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma (NPC)
Official Title: Phse II Study of Induction Chemotherapy With TPF Regimen Followed by Concurrent Chemoradiotherapy for Locally Advanced Nasopharyngeal Carcinoma
Study ID: NCT00817583
Conditions
Study Description
Brief Summary: The primary objective of this study is to determine the response rate, tolerance and overall survival in patients with stage III, IVa, IVb NPC treated with neoadjuvant chemotherapy (TPF regimen) and concurrent chemoradiation. Secondary objectives of the study are to evaluate the distant metastases free survival, and disease-free survival of patients with stage III,IVa, IVb NPC treated with this regimen. The third objective of this study is to evaluate who may benifit from this treatment regimen.
Detailed Description: Concurrent chemoradiation is the standard treatment for locally advanced NPC. The survival benefit gained from adding induction chemotherapy to concurrent chemoradiation has not been defined yet. In the present clinical study, we hope to assess the tolerance and survival benefits of induction chemotherapy followed by concurrent chemoradiation in patients with stage III, IVa and IVb NPC.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Department of Radiation Oncology, Cancer Hospital, Fudan University, Shanghai, Shanghai, China
Contact Details
Name: XiaoShen WANG, M.D.
Affiliation: Department of Radiation Oncology, Cancer Hospital, Fudan University
Role: PRINCIPAL_INVESTIGATOR
Name: ChaoSu HU, M.D.
Affiliation: Department of Radiation Oncology, Cancer Hospital, Fudan University
Role: STUDY_CHAIR
Name: ChunYing Shen, M.D.
Affiliation: Department of Radiation Oncology, Cancer Hospital, Fudan University
Role: PRINCIPAL_INVESTIGATOR
Name: HongMei Ying, M.D.
Affiliation: Department of Radiation Oncology, Cancer Hospital, Fudan University
Role: PRINCIPAL_INVESTIGATOR
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