Spots Global Cancer Trial Database for A Study of PF-07820435 as a Single Agent and in Combination in Participants With Advanced Solid Tumors
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Trial Identification
Brief Title: A Study of PF-07820435 as a Single Agent and in Combination in Participants With Advanced Solid Tumors
Official Title: A PHASE 1 DOSE ESCALATION AND EXPANSION STUDY TO EVALUATE SAFETY, TOLERABILITY, PHARMACOKINETIC, PHARMACODYNAMIC, AND ANTITUMOR ACTIVITY OF PF-07820435 AS MONOTHERAPY AND IN COMBINATION IN PARTICIPANTS WITH ADVANCED SOLID TUMORS
Study ID: NCT06285097
Study Description
Brief Summary: This study aims to evaluate the safety, and early signals of anti-tumor activity of PF-07820435 when administered alone (Part 1A) or in combination with sasanlimab (Part 1B; Part 2) in patients with selected advanced or metastatic solid tumors. Part 1 will be dose-finding and Part 2 of the study will further evaluate PF-07820435 at the recommended dose for combination expansion in patients with selected advanced solid tumors.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Florida Cancer Specialists Sarasota Drug Development Unit, Sarasota, Florida, United States
Corewell Health (reference non-engagement letter), Grand Rapids, Michigan, United States
START Midwest, Grand Rapids, Michigan, United States
Hackensack University Medical Center, Hackensack, New Jersey, United States
John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey, United States
Sarah Cannon Research Institute - Pharmacy, Nashville, Tennessee, United States
SCRI Oncology Partners, Nashville, Tennessee, United States
Tristar Centennial Medical Center, Nashville, Tennessee, United States
National Cancer Center Hospital East, Kashiwa, Chiba, Japan
The Cancer Institute Hospital of JFCR, Koto, Tokyo, Japan
Hospital Oncologico Dr. Isaac Gonzalez-Martinez, Rio Piedras, , Puerto Rico
Pan American Center for Oncology Trials, LLC, Rio Piedras, , Puerto Rico
Contact Details
Name: Pfizer CT.gov Call Center
Affiliation: Pfizer
Role: STUDY_DIRECTOR
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