Spots Global Cancer Trial Database for Next Generation Personalized Neuroblastoma Therapy
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Trial Identification
Brief Title: Next Generation Personalized Neuroblastoma Therapy
Official Title: Next Generation Personalized Neuroblastoma Therapy (The NEPENTHE Trial)
Study ID: NCT02780128
Study Description
Brief Summary: The purpose of this research study is to match genomic aberrations in tumor cells at time of relapse to rationally designed combinations of molecularly targeted agents. This study will be done in two parts: Part I: Tumor will be accessed at study entry via a biopsy and subjected to deep sequencing to identify protocol-specified biomarkers for therapy assignment. Part II: If the tumor contains a genetic change defined by the study as being actionable, and other criteria are met, participants will be assigned to therapy based upon the genetic changes identified in the tumor biopsy.
Detailed Description:
Eligibility
Minimum Age: 1 Year
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
Locations
The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
Contact Details
Name: Yael P Mossé, MD
Affiliation: Children's Hospital of Philadelphia, The University of Pennsylvania
Role: PRINCIPAL_INVESTIGATOR
Name: John M Maris, MD
Affiliation: Children's Hospital of Philadelphia, The University of Pennsylvania
Role: PRINCIPAL_INVESTIGATOR
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