Spots Global Cancer Trial Database for next generation sequencing
Every month we try and update this database with for next generation sequencing cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Neural Network-based Treatment Decision Support Tool in Patients With Refractory Solid Organ Malignancies | NCT05719428 | Solid Organ Mal... | DRUID AI Progra... | 21 Years - 99 Years | National University Hospital, Singapore | |
| Targeted Next Generation Sequencing for the Efficacy of Trastuzumab Neoadjuvant Chemotherapy in Breast Cancer | NCT03728829 | Observational Prospective | Trastuzumab+TP | 18 Years - 70 Years | Hebei Medical University Fourth Hospital | |
| A Study of Venetoclax and ABBV-838 Combination Therapy With Dexamethasone in Participants With Multiple Myeloma Whose Cancer Has Come Back or Had No Response to Recent Cancer Treatment | NCT02951117 | Multiple Myelom... | Venetoclax ABBV-838 Dexamethasone | 18 Years - 99 Years | AbbVie | |
| Dynamic Monitoring Circulating Tumor DNA in Surgical Patients With Lung Cancer | NCT03317080 | Lung Cancer | - | West China Hospital | ||
| NGS in Gallbladder Cancer and Response to Treatment | NCT05404347 | Gallbladder Can... | Next generation... | 18 Years - 99 Years | Banaras Hindu University | |
| Matching Patients With Hematologic Malignancy to Adequate Clinical Trials | NCT02758080 | Hematologic Mal... | Matching on the... Matching on the... | 18 Years - | Seoul National University Hospital | |
| Neural Network-based Treatment Decision Support Tool in Patients With Refractory Solid Organ Malignancies | NCT05719428 | Solid Organ Mal... | DRUID AI Progra... | 21 Years - 99 Years | National University Hospital, Singapore | |
| Biomarker Study of Pts With Metastatic ccRCC Undergoing Sequential Therapy With 1st Line Sunitinib and 2nd Line Axitinib | NCT03592199 | Clear Cell Rena... | Sunitinib | 18 Years - | Instituto do Cancer do Estado de São Paulo | |
| Sensitivity and Specificity of NGS in Detecting bMSI in Patients With Gastric, Duodenal and Small Intestinal Cancer | NCT03915171 | Gastrointestina... | Next generation... | 18 Years - | China Medical University, China | |
| A Clinical Test for the Treatment of Multifocal Lung Cancers Using Genome Sequencing | NCT02705404 | Lung Neoplasms Carcinoma Non-s... | Multifocal Tiss... | 18 Years - | Mayo Clinic | |
| Biomarker Study of Pts With Metastatic ccRCC Undergoing Sequential Therapy With 1st Line Sunitinib and 2nd Line Axitinib | NCT03592199 | Clear Cell Rena... | Sunitinib | 18 Years - | Instituto do Cancer do Estado de São Paulo | |
| Radiogenomics in Aerodigestive Tract Cancers | NCT04314349 | Cancer, Lung Cancer of Esoph... Cancer of Head ... | 20 Years - | Buddhist Tzu Chi General Hospital | ||
| Predictive Biomarkers Including miRNA-based Tumor Signatures in Diffuse Large B Cell Lymphoma (R/R DLBCL) (MIMOSA) | NCT05746858 | Diffuse Large B... Relapsed Non-Ho... | no intervention... | 18 Years - | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | |
| A Study to Examine the Clinical Value of Comprehensive Genomic Profiling Performed by Belgian NGS Laboratories: a Belgian Precision Study of the BSMO in Collaboration With the Cancer Centre | NCT05058937 | Solid Tumor Metastatic Canc... | Comprehensive g... | 18 Years - | The Belgian Society of Medical Oncology | |
| Treatment of Multifocal Lung Adenocarcinoma | NCT01946100 | Lung Neoplasms Carcinoma Non-s... Adenocarcinoma | Multifocal Lung... | 18 Years - | Mayo Clinic | |
| Tumor Heterogeneity in Diffuse Large B-cell Lymphoma in Relation to CNS Involvement and Cell-free DNA | NCT04763148 | Lymphoma, Large... | 18 Years - | Herlev Hospital | ||
| Indwelling Device-associated Biofilms | NCT04328818 | Oncology Critical Illnes... Sepsis Hospital Infect... | indwelling devi... | 18 Years - | Grigore T. Popa University of Medicine and Pharmacy | |
| Molecular Profiling to Improve Outcome of Patients in Cancer. A Pilot Study | NCT03546127 | Colorectal Carc... Soft Tissue Sar... | Next Generation... | 18 Years - | Institut National de la Santé Et de la Recherche Médicale, France | |
| Clinical Value of Next Generation Sequencing in Endocrine Therapy for Advanced Hormone Receptor Positive/HER-2 Negative Breast Cancer | NCT03786575 | Breast Neoplasm... Therapeutics Mutation | Next Generation... | 18 Years - | Peking Union Medical College | |
| Study to Assess the Feasibility in Bile cfDNA of Resectable Biliary Tract Carcinomas | NCT05783973 | This Study Aims... | Next generation... | 18 Years - | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | |
| UC-GENOME: Urothelial Cancer-GENOmic Analysis to iMprove Patient Outcomes and rEsearch | NCT02643043 | Urothelial Carc... Bladder Cancer Urethral Cancer Cancer of the U... | Biospecimen Col... | 18 Years - | Hoosier Cancer Research Network | |
| Validation of Molecular Diagnostic Thecnologies for Lung Cancer Patients. | NCT03220230 | Lung Neoplasms | 18 Years - | Pfizer | ||
| Mutational Analysis as a Prognostic and Predictive Marker of Cardiovascular (CVD) Disease in Patients With Myelodysplasia | NCT04110925 | MDS Cardiovascular ... Inflammation | Genetic Mutatio... Inflammatory an... Computed Tomogr... | - | Sunnybrook Health Sciences Centre | |
| GENESIS: Genetic Biopsy for Prediction of Surveillance Intervals After Endoscopic Resection of Colonic Polyps | NCT02595645 | Colonic Polyps | Polypectomy and... | 18 Years - | University of Ulm | |
| Next Generation Personalized Neuroblastoma Therapy | NCT02780128 | Neuroblastoma Cancer | Biopsy Next Generation... Tumor Scans Bone marrow Tes... Physical Exam Eye Exam Labs Pregnancy Test Interviews ECG Echocardiogram Ribociclib Ceritinib | 1 Year - 21 Years | Children's Hospital of Philadelphia | |
| Molecular Profiling to Improve Outcome of Patients in Cancer. A Pilot Study | NCT03546127 | Colorectal Carc... Soft Tissue Sar... | Next Generation... | 18 Years - | Institut National de la Santé Et de la Recherche Médicale, France | |
| Screening Gene Mutations in Myeloid Cancers by Next Generation Sequencing to Improve Treatment Results | NCT04060485 | Acute Myeloid L... Myelodysplastic... Myeloproliferat... Aplastic Anemia | 18 Years - 120 Years | National Taiwan University Hospital | ||
| Development of Biomarker for the Evaluation of Response After Neoadjuvant Therapy in Patients With Pancreatic Cancer | NCT04110769 | Genetic Change Chemotherapy Ef... Pancreatic Canc... | next generation... following next ... | 20 Years - | Asan Medical Center | |
| KEAPSAKE: A Study of Telaglenastat (CB-839) With Standard-of-Care Chemoimmunotherapy in 1L KEAP1/NRF2-Mutated, Nonsquamous NSCLC | NCT04265534 | Non-Small Cell ... Non-squamous No... Non-Squamous No... KEAP1 Gene Muta... NRF2 Gene Mutat... NFE2L2 Gene Mut... | Telaglenastat Carboplatin Che... Pemetrexed Chem... Pembrolizumab I... Placebo Folic acid 400 ... Vitamin B12 100... Dexamethasone 4... | 18 Years - | Calithera Biosciences, Inc | |
| Radiogenomics in Aerodigestive Tract Cancers | NCT04314349 | Cancer, Lung Cancer of Esoph... Cancer of Head ... | 20 Years - | Buddhist Tzu Chi General Hospital | ||
| Characteristics and Dynamics of TCR Repertoire in Patients With Hematological Malignancies After Allo-HSCT | NCT03575767 | Hematologic Neo... Hematopoietic S... Graft Vs Host D... Recurrence | Myeloablative H... | 12 Years - 55 Years | Affiliated Hospital to Academy of Military Medical Sciences | |
| Matching Patients With Hematologic Malignancy to Adequate Clinical Trials | NCT02758080 | Hematologic Mal... | Matching on the... Matching on the... | 18 Years - | Seoul National University Hospital | |
| Prospective Evaluation of Diagnosis and Treatment of Patients With Autoimmune Cytopenias Including Autoimmune Hemolytic Anemia, Immune Thrombocytopenia, and Chronic Idiopathic/Autoimmune Neutropenia | NCT05931718 | Autoimmune Hemo... Immune Thromboc... Chronic Idiopat... Autoimmune Neut... Myelodysplastic... Cold Agglutinin... | cytokine essays NGS Fecal microbiom... Erythropoietin Luspatercept Thrombopoietin ... G-CSF | 18 Years - | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | |
| DNA-mutation Analysis in Cyst Fluid of Suspected Intraductal Papillary Mucinous Neoplasia of the Pancreas | NCT03820531 | Pancreas Cyst | Next Generation... CEA and lipase Cytology Histology of re... | 18 Years - | Theresienkrankenhaus und St. Hedwig-Klinik GmbH | |
| A Clinical Test for the Treatment of Multifocal Lung Cancers Using Genome Sequencing | NCT02705404 | Lung Neoplasms Carcinoma Non-s... | Multifocal Tiss... | 18 Years - | Mayo Clinic | |
| Non-Invasive Diagnostics of Small Renal Masses | NCT03667885 | Renal Cell Carc... Renal Tumor | Blood sample urine sample Multi planar MR... | 18 Years - | Odense University Hospital | |
| Feasibility of Bronchial Washing Fluid for Molecular Testing With Next Generation Sequencing in Lung Cancer | NCT06141005 | Lung Cancer | Ultrathin bronc... | 20 Years - | Pusan National University Hospital | |
| TCF-001 TRACK (Target Rare Cancer Knowledge) Study | NCT04504604 | Rare Cancers Cholangiocarcin... Cancer of Unkno... | FoundationOne C... | 18 Years - | TargetCancer Foundation | |
| Prospective Evaluation of Diagnosis and Treatment of Patients With Autoimmune Cytopenias Including Autoimmune Hemolytic Anemia, Immune Thrombocytopenia, and Chronic Idiopathic/Autoimmune Neutropenia | NCT05931718 | Autoimmune Hemo... Immune Thromboc... Chronic Idiopat... Autoimmune Neut... Myelodysplastic... Cold Agglutinin... | cytokine essays NGS Fecal microbiom... Erythropoietin Luspatercept Thrombopoietin ... G-CSF | 18 Years - | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | |
| Newer Therapeutic Targets in Head and Neck Cancers | NCT05382585 | Head Neck Cance... Oral Cancer | Next generation... | 18 Years - 100 Years | Banaras Hindu University | |
| Analysis of Re-biopsy Specimens in Advanced NSCLC With Acquired Resistance of EGFR-TKI Targeted Therapy | NCT03309462 | Lung Cancer | Miseq sequencer | 18 Years - 80 Years | Shanghai Chest Hospital | |
| Ontario-wide Cancer TArgeted Nucleic Acid Evaluation | NCT02906943 | Breast Cancer Lung Cancer Colorectal Canc... Melanoma Gynecological C... Genitourinary C... Pancreatobiliar... Gastrointestina... Head and Neck C... Rare Cancer Unknown Primary... | 18 Years - | University Health Network, Toronto | ||
| Utility of EUS-guided Microbiopsies in Pancreatic Cystic Lesions | NCT03578445 | Pancreatic Cyst IPMN Mucinous Cyst Pancreatic Aden... | EUS-guided micr... Next Generation... | 18 Years - | Herlev Hospital | |
| Cancer Genome Analysis | NCT01458704 | Malignant Tumor | next generation... | 18 Years - | Seoul National University Hospital | |
| The Registry of Genetic Alterations of Taiwan Ovarian Cancer | NCT06127446 | Ovarian Cancer | 18 Years - | National Health Research Institutes, Taiwan | ||
| Evaluation of Efficacy of Comprehensive Genomic Tumour Profiling (CGP) From Liquid and/or Tissue Biopsy in Patients With Locally Advanced and/or Metastatic Carcinoma | NCT05032092 | Locally Advance... Metastatic Canc... | Next Generation... Next Generation... Biomarker Monit... | 18 Years - | Medical University of Graz | |
| Clinical Value of Next Generation Sequencing in Endocrine Therapy for Advanced Hormone Receptor Positive/HER-2 Negative Breast Cancer | NCT03786575 | Breast Neoplasm... Therapeutics Mutation | Next Generation... | 18 Years - | Peking Union Medical College | |
| Real-Time Monitoring of Circulating Tumor DNA and Study of Prognostic Factors in Patients Treated With CAR-T Cells | NCT05675982 | Diffuse Large B... | CAR-T cells mon... | 18 Years - | Centre Henri Becquerel | |
| System Biology of Spleen Deficiency Syndrome | NCT02915393 | Gastritis, Atro... Gastric Cancer | 18 Years - 65 Years | Beijing University of Chinese Medicine | ||
| Cancer Genome Analysis | NCT01458704 | Malignant Tumor | next generation... | 18 Years - | Seoul National University Hospital | |
| KEAPSAKE: A Study of Telaglenastat (CB-839) With Standard-of-Care Chemoimmunotherapy in 1L KEAP1/NRF2-Mutated, Nonsquamous NSCLC | NCT04265534 | Non-Small Cell ... Non-squamous No... Non-Squamous No... KEAP1 Gene Muta... NRF2 Gene Mutat... NFE2L2 Gene Mut... | Telaglenastat Carboplatin Che... Pemetrexed Chem... Pembrolizumab I... Placebo Folic acid 400 ... Vitamin B12 100... Dexamethasone 4... | 18 Years - | Calithera Biosciences, Inc | |
| Evaluation of Efficacy of Comprehensive Genomic Tumour Profiling (CGP) From Liquid and/or Tissue Biopsy in Patients With Locally Advanced and/or Metastatic Carcinoma | NCT05032092 | Locally Advance... Metastatic Canc... | Next Generation... Next Generation... Biomarker Monit... | 18 Years - | Medical University of Graz | |
| Surgery Impact on Circulating Tumor DNA in Pancreatic Cancer | NCT03435536 | Resectable Panc... | Blood samples | 18 Years - | University Hospital, Toulouse | |
| TCF-001 TRACK (Target Rare Cancer Knowledge) Study | NCT04504604 | Rare Cancers Cholangiocarcin... Cancer of Unkno... | FoundationOne C... | 18 Years - | TargetCancer Foundation | |
| Prognostic Biomarkers in Patients With Urothelial Carcinoma | NCT04872036 | Bladder Cancer | 18 Years - | Hellenic Cooperative Oncology Group | ||
| A Study of Venetoclax and ABBV-838 Combination Therapy With Dexamethasone in Participants With Multiple Myeloma Whose Cancer Has Come Back or Had No Response to Recent Cancer Treatment | NCT02951117 | Multiple Myelom... | Venetoclax ABBV-838 Dexamethasone | 18 Years - 99 Years | AbbVie | |
| Identification of Molecular Biomarkers for Cancer Target Therapy Efficacy | NCT03724097 | Cancer | RNA sequencing Transcriptome a... target drug wit... target drug wit... non-target drug palliative care | 18 Years - 80 Years | OmicsWay Corp. | |
| Predictive Biomarkers Including miRNA-based Tumor Signatures in Diffuse Large B Cell Lymphoma (R/R DLBCL) (MIMOSA) | NCT05746858 | Diffuse Large B... Relapsed Non-Ho... | no intervention... | 18 Years - | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | |
| Circulating Tumor DNA in Primary Mediastinal Large B-cell Lymphoma (PMBL) | NCT04824950 | Primary Mediast... | Circulating tum... | 18 Years - | Centre Henri Becquerel | |
| BCL6-rearrangements Implications in Non-Hodgkin Lymphomas. | NCT06424379 | Non Hodgkin Lym... Follicular Lymp... Marginal Zone L... Diffuse Large B... | Histopathologic... Molecular analy... | 25 Years - 100 Years | Hospices Civils de Lyon | |
| Prognostic Significance of ctDNA in HL | NCT06263530 | Prognostic Canc... | 18 Years - | Interni hematologicka klinika FNKV | ||
| Multi-site HPV Screening by High-throughput Sequencing in Patients With Chronic HPV-HR Infection Followed by Gynecology | NCT04901351 | Human Papilloma... | Smear | 18 Years - | University Hospital, Toulouse | |
| UC-GENOME: Urothelial Cancer-GENOmic Analysis to iMprove Patient Outcomes and rEsearch | NCT02643043 | Urothelial Carc... Bladder Cancer Urethral Cancer Cancer of the U... | Biospecimen Col... | 18 Years - | Hoosier Cancer Research Network | |
| Mutational Analysis as a Prognostic and Predictive Marker of Cardiovascular (CVD) Disease in Patients With Myelodysplasia | NCT04110925 | MDS Cardiovascular ... Inflammation | Genetic Mutatio... Inflammatory an... Computed Tomogr... | - | Sunnybrook Health Sciences Centre | |
| TCF-001 TRACK (Target Rare Cancer Knowledge) Study | NCT04504604 | Rare Cancers Cholangiocarcin... Cancer of Unkno... | FoundationOne C... | 18 Years - | TargetCancer Foundation | |
| Unified platforM for a Better integRal Evaluation of MyeLodyspLastic Syndromes in SpAin-Strategy for Unraveling Personalized genoMic Medicine in Public heAlth System (UMBRELLA-SUMMA) | NCT06379945 | Myelodysplastic... | 18 Years - | Instituto de Investigación Biomédica de Salamanca | ||
| Matching Patients With Hematologic Malignancy to Adequate Clinical Trials | NCT02758080 | Hematologic Mal... | Matching on the... Matching on the... | 18 Years - | Seoul National University Hospital | |
| POA Prospective Repository | NCT03324841 | Solid Tumor, Ad... Oncology | Caris MI Profil... | 18 Years - | Caris Science, Inc. | |
| Feasibility of Bronchial Washing Fluid for Molecular Testing With Next Generation Sequencing in Lung Cancer | NCT06141005 | Lung Cancer | Ultrathin bronc... | 20 Years - | Pusan National University Hospital | |
| Development of Biomarker for the Evaluation of Response After Neoadjuvant Therapy in Patients With Pancreatic Cancer | NCT04110769 | Genetic Change Chemotherapy Ef... Pancreatic Canc... | next generation... following next ... | 20 Years - | Asan Medical Center | |
| A Study to Identify a Biomarker Predictive for Response on Everolimus in Solid Tumors (CPCT-03) | NCT01566279 | Unspecified Adu... | Everolimus | 18 Years - | UMC Utrecht | |
| Cancer Predisposition Testing by Family-based Whole-genome Sequencing (WGS) in Every Child With Newly Diagnosed Cancer | NCT04903782 | Neoplastic Synd... Cancer Genetic Predisp... | Family-based wh... | - 21 Years | Sydney Children's Hospitals Network | |
| Molecular Disease Profile of Hematological Malignancies | NCT02459743 | Hematological M... | 18 Years - | University of Pavia | ||
| The Registry of Genetic Alterations of Taiwan Ovarian Cancer | NCT06127446 | Ovarian Cancer | 18 Years - | National Health Research Institutes, Taiwan | ||
| Circulating Tumor DNA in Primary Mediastinal Large B-cell Lymphoma (PMBL) | NCT04824950 | Primary Mediast... | Circulating tum... | 18 Years - | Centre Henri Becquerel | |
| A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations | NCT05199584 | Solid Tumors Wi... | ENV-101 (talade... | 18 Years - | Endeavor Biomedicines, Inc. | |
| Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing | NCT04981119 | Solid Tumor, Ad... Colorectal Canc... Non Small Cell ... Pancreatic Canc... CRC NSCLC Pancreas Cancer Mesothelioma Ovarian Cancer Ovarian Neoplas... Ovarian Carcino... Mesothelioma, M... Mesothelioma; L... Cancer | Apheresis Next Generation... Long Range NGS ... | 18 Years - | A2 Biotherapeutics Inc. | |
| Surgery Impact on Circulating Tumor DNA in Pancreatic Cancer | NCT03435536 | Resectable Panc... | Blood samples | 18 Years - | University Hospital, Toulouse | |
| Personalized Therapy of Molecular Tumor Board Participation With the Guidance of Next Generation Sequencing | NCT03929653 | Solid Tumor, Ad... | Personalized th... | 18 Years - | Tianjin Medical University Second Hospital | |
| Biomarker Evaluation in Advanced Stage Cervical Cancer by an International Working Group. Tumor Stages (1B1 - 4) | NCT02428842 | Cervical Cancer | Tumor biopsies Blood sampling | 18 Years - | Institut Curie |
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