Spots Global Cancer Trial Database for Best Therapy for Patients With Neuroendocrine Tumors

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Trial Identification

Brief Title: Best Therapy for Patients With Neuroendocrine Tumors

Official Title: Best Therapy for Patients With Neuroendocrine Tumors

Study ID: NCT00815620

Conditions

Neuroendocrine Tumors

Interventions

Study Description

Brief Summary: A prospective observational study containing three arms comprising different therapeutic measures to treat patients with neuroendocrine tumors in advanced stages. The therapy arms include local ablative therapy such as TACE or SIRT, surgery and RFA with peptide receptor radiotherapy.

Detailed Description: Study design: Prospective observational study comparing ablative measures as TACE or SIRT with surgery/RFA and with peptide receptor radio-therapy in patients with advanced well-differentiated neuroendocrine tumors with lymph node or distant metastases (N1, M1) Prospective evaluation Primary end points: time to progression Secondary end points: survival, quality of life (EORTC-QLQ30), weight, time of hospitalization, Karnofsky index) Non-randomized cohort study Number of patients needed in all groups: 70 per group, 210 overall Evaluation of response to therapy every 3-6 months by imaging, clinical status, weight, quality of life, Karnofsky-index Cross-over allowed if therapy changes