Spots Global Cancer Trial Database for A Study Evaluating the Safety and Pharmacokinetics of ABT-199 in Combination With Bendamustine/Rituximab (BR) in Subjects With Relapsed or Refractory Non-Hodgkin's Lymphoma
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Trial Identification
Brief Title: A Study Evaluating the Safety and Pharmacokinetics of ABT-199 in Combination With Bendamustine/Rituximab (BR) in Subjects With Relapsed or Refractory Non-Hodgkin's Lymphoma
Official Title: A Phase 1 Study Evaluating the Safety and Pharmacokinetics of ABT-199 in Combination With Bendamustine/Rituximab (BR) in Subjects With Relapsed or Refractory Non-Hodgkin's Lymphoma
Study ID: NCT01594229
Conditions
Study Description
Brief Summary: This is a Phase 1, open-label, multicenter study evaluating the safety, pharmacokinetic profile, and preliminary efficacy of ABT-199 in combination with Bendamustine/Rituximab in approximately 60 subjects with relapsed or refractory non-Hodgkin's lymphoma. This study will evaluate the safety and pharmacokinetic profile of ABT-199 in approximately 60 subjects when administered in combination with Bendamustine/Rituximab following a dose escalation scheme, with the objective of defining the dose limiting toxicity and the maximum tolerated dose.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Ucsd /Id# 67350, La Jolla, California, United States
University of California, Los Angeles /ID# 67343, Los Angeles, California, United States
Emory University Hospital /ID# 67349, Atlanta, Georgia, United States
Georgia Regents University /ID# 67342, Augusta, Georgia, United States
Ingalls Memorial Hosp /ID# 67344, Harvey, Illinois, United States
Johns Hopkins University /ID# 67345, Baltimore, Maryland, United States
Henry Ford Health System /ID# 67346, Detroit, Michigan, United States
University of Texas MD Anderson Cancer Center /ID# 69222, Houston, Texas, United States
Contact Details
Name: AbbVie Inc.
Affiliation: AbbVie
Role: STUDY_DIRECTOR
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