Spots Global Cancer Trial Database for Prophylactic Cranial Irradiation (PCI) vs Observation in Stage III NSCLC
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Trial Identification
Brief Title: Prophylactic Cranial Irradiation (PCI) vs Observation in Stage III NSCLC
Official Title: Prophylactic Cranial Irradiation (PCI) Versus Observation in Radically Treated Patients With Stage III Non-small Cell Lung Cancer; A Phase III Randomized Study.
Study ID: NCT01282437
Interventions
Study Description
Brief Summary: For patients with stage III non-small cell lung cancer, which is radically treated, we will investigate whether prophylactic cranial irradiation (PCI) should become standard of care to prevent brain metastases.
Detailed Description: For this group of patients, brain metastases are one of the major sites of tumor failure. Radical therapy of symptomatic brain metastases is seldom possible and only very rarely, long term survival can be achieved. PCI has shown to reduce the incidence of brain metastases in patients with non-small cell lung cancer to the same extent as in limited disease small-cell lung cancer. However, the exact value of PCI in stage III NSCLC patient, treated with contemporary chemo-radiation schedule with or without surgery, remains unsettled. Therefore this study is launched, in order to investigate whether PCI should become the standard of care in patients with stage III NSCLC who are treated with curative intention.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Maastro Clinic, Maastricht, Limburg, Netherlands
The Netherlands Cancer Institute, Amsterdam, , Netherlands
VU Medical Center, Amsterdam, , Netherlands
RT Insitute Stedendriehoek, Deventer, , Netherlands
UMCG Groningen, Groningen, , Netherlands
St. Antonius Ziekenhuis, Nieuwegein, , Netherlands
Dr. Bernard Verbeeten Institute, Tilburg, , Netherlands
UMC Utrecht, Utrecht, , Netherlands
Isala Klinieken, Zwolle, , Netherlands
Contact Details
Name: Dirk De Ruysscher, MD, PhD
Affiliation: NVALT oncology foundation
Role: PRINCIPAL_INVESTIGATOR
Name: Harry Groen, MD, PhD
Affiliation: University Medical Center Groningen
Role: PRINCIPAL_INVESTIGATOR
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