Spots Global Cancer Trial Database for Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients
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Trial Identification
Brief Title: Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients
Official Title: A Phase 1/2 Study of Avutometinib (VS-6766) in Combination With Adagrasib in Patients With KRAS G12C Mutant Non-Small Cell Lung Cancer (NSCLC) (RAMP 204)
Study ID: NCT05375994
Interventions
Study Description
Brief Summary: This study will assess the safety and efficacy of avutometinib (VS-6766) in combination with adagrasib in patients with G12C Non-Small Cell Lung Cancer (NSCLC) who have been exposed to prior G12C inhibitor and experienced progressive disease.
Detailed Description: This is a multicenter, non-randomized, open-label Phase 1/2 study designed to evaluate safety, tolerability and efficacy of avutometinib (VS-6766) in combination with adagrasib in patients with KRAS G12C mutant NSCLC who have been exposed to prior G12C inhibitor and experienced progressive disease.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
UCSF Thoracic Oncology, San Francisco, California, United States
University of Colorado Hospital Anschutz Cancer Pavllion, Aurora, Colorado, United States
Mayo Clinic Cancer Center, Jacksonville, Florida, United States
Mayo Clinic Cancer Center, Rochester, Minnesota, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
Virginia Cancer Specialists, NEXT Oncology, Fairfax, Virginia, United States
Medical College Wisconsin, Milwaukee, Wisconsin, United States
Contact Details
Name: MD Verastem
Affiliation: Verastem, Inc.
Role: STUDY_DIRECTOR
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