Spots Global Cancer Trial Database for Randomized Trial of Docetaxel and Gemcitabine Versus Gemcitabine in Elderly Patients With NSCLC
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Trial Identification
Brief Title: Randomized Trial of Docetaxel and Gemcitabine Versus Gemcitabine in Elderly Patients With NSCLC
Official Title: A Multicenter Randomized Phase III Study of the Docetaxel and Gemcitabine Combination Versus Monotherapy With Gemcitabine as First-line Treatment in Elderly Patients With Advanced Non-Small-Cell Lung Cancer (NSCLC)
Study ID: NCT00442026
Conditions
Study Description
Brief Summary: This trial will compare the efficacy of the docetaxel and gemcitabine combination versus monotherapy with gemcitabine as first-line treatment in elderly patients with advanced NSCLC
Detailed Description: Docetaxel and gemcitabine are well known active agents in the treatment of NSCLC. The standard treatment of elderly patients with advanced NSCLC is monotherapy with a third generation agent. However, there are only few randomized trials evaluating a two drug combination specifically addressed to elderly patients. The role of comprehensive geriatric assessment in treatment efficacy and tolerance is an area of investigation
Eligibility
Minimum Age: 70 Years
Eligible Ages: OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University General Hospital of Alexandroupolis, Dep of Medical Oncology, Alexandroupolis, , Greece
"Laikon" General Hospital, Medical Oncology Unit, Propedeutic Dep of Internal Medicine, Athens, , Greece
401 Military Hospital, Medical Oncology Unit, Athens, , Greece
Air Forces Military Hospital, Dep of Medical Oncology, Athens, , Greece
IASO" General Hospital of Athens, 1st Dep of Medical Oncology, Athens, , Greece
Sismanogleio General Hospital, 1st, 2nd Dep of Pulmonary Diseases, Athens, , Greece
Sotiria" General Hospital, 1st, 3rd, 8th Dep of Pulmonary Diseases, Athens, , Greece
"Metaxa's" Anticancer Hospital of Piraeus,1st Dep of Medical Oncology, Piraeus, , Greece
Theagenion" Anticancer Hospital of Thessaloniki, Thessaloniki, , Greece
Contact Details
Name: Lampros Vamvakas, MD
Affiliation: University Hospital of Crete, Dep of Medical Oncology
Role: PRINCIPAL_INVESTIGATOR
Name: Athanasios Karampeazis, MD
Affiliation: University Hospital of Crete
Role: PRINCIPAL_INVESTIGATOR
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