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Spots Global Cancer Trial Database for Stereotactic Body Radiotherapy Versus Conventional Radiotherapy in Medically-Inoperable Non-Small Lung Cancer Patients

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Trial Identification

Brief Title: Stereotactic Body Radiotherapy Versus Conventional Radiotherapy in Medically-Inoperable Non-Small Lung Cancer Patients

Official Title: A Randomized Trial of Medically-Inoperable Stage 1 Non-small Cell Lung Cancer Patients Comparing Stereotactic Body Radiotherapy Versus Conventional Radiotherapy

Study ID: NCT01968941

Study Description

Brief Summary: A multi-centre randomized controlled open-label trial in medically inoperable patients with biopsy-proven early stage non-small cell lung cancer (NSCLC). Eligible and consenting patients will be randomly allocated to receive stereotactic body radiotherapy (SBRT) or conventional radiotherapy (CRT) in a 2:1 ratio. Radiotherapy will be administered as soon as possible following randomization and subjects will be followed for 5 years post-randomization for cancer recurrence, toxicity and survival. The primary outcome is local control (LC). The trial will be conducted at 16-20 clinical centres throughout Canada.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Tom Baker Cancer Centre, Calgary, Alberta, Canada

Cross Cancer Institute, Edmonton, Alberta, Canada

Cancer Care Manitoba, Winnipeg, Manitoba, Canada

Horizon Health Network, Saint John, New Brunswick, Canada

Juravinski Hospital and Cancer Centre, Hamilton, Ontario, Canada

Cancer Centre of Southeastern Ontario at the Kingston General Hospital, Kingston, Ontario, Canada

London Regional Cancer Program at London Health Sciences Centre, London, Ontario, Canada

Niagara Health System-Walker Family Cancer Centre, St. Catharines, Ontario, Canada

Thunder Bay Regional Health Sciences Centre, Thunder Bay, Ontario, Canada

Windsor Regional Cancer Centre, Windsor, Ontario, Canada

Charles LeMoyne Hospital, Greenfield Park, Quebec, Canada

CHUM Hospital Notre Dame, Montreal, Quebec, Canada

Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada

Montreal General Hospital McGill, Montreal, Quebec, Canada

Allan Blair Cancer Centre, Regina, Saskatchewan, Canada

Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada

Contact Details

Name: Anand Swaminath

Affiliation: Ontario Clinical Oncology Group (OCOG)

Role: PRINCIPAL_INVESTIGATOR

Name: Tim Whelan

Affiliation: Ontario Clinical Oncology Group (OCOG)

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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