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Brief Title: A Clinica Study of Pyrotinib in Patients of Advanced Non-Small Cell Lung Cancer With HER2 Mutation
Official Title: A Phase 2 Clinica Study: Efficacy and Safety of Pyrotinib in Patients of Advanced Non-Small Cell Lung Cancer With HER2 Mutation
Study ID: NCT02834936
Brief Summary: This study is designed to evaluate the efficacy and safety of Pyrotinib in patients of advanced pre-treated Non-small cell lung cancer With HER2 Mutation. To observe objective response rate (ORR) of pyrotinib in NSCLC With HER2 Mutation. To observe Progression free survival (PFS). To assess the overall survival (OS). A secondary aim is to obtain safety information. To explore the relationship between biomarkers and the toxicity/efficacy of Pyrotinib.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Shanghai Pulmonary Hospital, Shanghai, Shanghai, China
HR-BLTN-II-NSCLC Investigational Site, Beijing, , China
HR-BLTN-II-NSCLC Investigational Site, Changsha, , China
HR-BLTN-II-NSCLC Investigational Site, Guangzhou, , China
HR-BLTN-II-NSCLC Investigational Site, Hangzhou, , China
HR-BLTN-II-NSCLC Investigational Site, Harbin, , China
HR-BLTN-II-NSCLC Investigational Site, Nanjing, , China
HR-BLTN-II-NSCLC Investigational Site, Shanghai, , China
HR-BLTN-II-NSCLC Investigational Site, Suzhou, , China
HR-BLTN-II-NSCLC Investigational Site, Wuhan, , China
HR-BLTN-II-NSCLC Investigational Site, Zhengzhou, , China