Spots Global Cancer Trial Database for Study Comparing Bevacizumab + Erlotinib vs Erlotinib Alone as First Line Treatment of Patients With EGFR Mutated Advanced Non Squamous Non Small Cell Lung Cancer
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Trial Identification
Brief Title: Study Comparing Bevacizumab + Erlotinib vs Erlotinib Alone as First Line Treatment of Patients With EGFR Mutated Advanced Non Squamous Non Small Cell Lung Cancer
Official Title: A Randomized Open-label Phase 3 Trial Comparing Bevacizumab + Erlotinib vs Erlotinib Alone as First Line Treatment of Patients With EGFR Mutated Advanced Non Squamous Non Small Cell Lung Cancer
Study ID: NCT02633189
Conditions
Study Description
Brief Summary: The purpose of this study is to test whether the combination of bevacizumab and erlotinib can prolong progression free survival as compared with erlotinib alone as first-line treatment in patients with non small cell lung cancer (NSCLC) with activating mutation of EGFR.
Detailed Description: The co-primary objectives are to assess investigator-assess, and blinded independent centrally-reviewed progression-free survival .
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Ospedale Ramazzini, Day Hospital Oncologico, Carpi, MO, Italy
Casa di Cura La Maddalena S.p.A., Dipartimento Oncologico, Palermo, PA, Italy
Ospedale di Prato, Prato, PO, Italy
Ospedale S. Chiara, Trento, TN, Italy
Ospedale S. Bortolo ULSS 6, U.O. di Oncologia Medica, Vicenza, VI, Italy
A.S.O. SS Antonio e Biagio e Cesare Arrigo, Alessandria, , Italy
A.O. S. Giuseppe Moscati, Avellino, , Italy
Centro Riferimento Oncologico, Aviano, , Italy
AO G. Rummo, Benevento, , Italy
Ospedale Senatore Antonio Perrino, Brindisi, , Italy
Ospedale A. cardarelli, Campobasso, , Italy
U.L.S.S. 15 Veneto, Camposampiero, , Italy
A.O. Garibaldi Nesima, Catania, , Italy
Centro Clinico Diagnostico G.B. Morgagni, Catania, , Italy
Policlinico vittorio Emanuele, Catania, , Italy
Ospedale Civile per gli Infermi, Faenza, , Italy
Ospedale S. Croce, Fano, , Italy
A.O.U. Arcispedale Sant'Anna, Ferrara, , Italy
Ospedale Villa Scassi, Genova, , Italy
Ospedale di Guastalla, Guastalla, , Italy
A.O. Vito Fazzi, Lecce, , Italy
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, , Italy
Istituto Europeo di Oncologia, Milano, , Italy
Istituto Nazionale Tumori, Milano, , Italy
Ospedale San Paolo, Milano, , Italy
A.O. U.L.S.S. 13, Mirano, , Italy
A.O.U. Policlinico Modena, Modena, , Italy
Azienda Ospedaliera Cardarelli, Napoli, , Italy
A.O.U. Seconda Università di Napoli, Napoli, , Italy
AORN Ospedale dei Colli - Osp Monaldi, Napoli, , Italy
Istituto Nazionale Tumori Fondazione G. Pascale, Napoli, , Italy
Istituto Sacro Cuore Don Calabria, Negrar, , Italy
A.O.U. Maggiore della Carità, Novara, , Italy
Istituto Oncologico Veneto, Padova, , Italy
Policlinico Giaccone, Palermo, , Italy
Fondazione Salvatore Maugeri, Pavia, , Italy
Osp. S. Maria della Misericordia, Perugia, , Italy
A.O. Ospedali Riuniti Marche Nord, Pesaro, , Italy
Ospedale Guglielmo da Saliceto, Piacenza, , Italy
A.O. San Carlo, Potenza, , Italy
Ospedale Santa Maria delle Croci - AUSL, Ravenna, , Italy
Ospedale Umberto I, Ravenna, , Italy
Ospedale degli Infermi Rimini - Ospedale Cervesi Cattolica, Rimini, , Italy
IRCCS Centro di Riferimento Oncologico Basilicata, Rionero in Vulture, , Italy
Istituto Regina Elena, Roma, , Italy
Ospedale Camillo Forlanini, Roma, , Italy
Ospedale S. Giovanni Calibita Fatebenefratelli, Roma, , Italy
Policlinico Universitario Campus Bio Medico, Roma, , Italy
Ospedale di Sondrio, Sondrio, , Italy
Ospedale Fabrizio Spaziani di Frosinone, Sora, , Italy
Ospedale Maggiore, Trieste, , Italy
Azienda Ospedaliero-Universitaria S.M. della Misericordia di Udine, Udine, , Italy
Ospedale S. Andrea, Vercelli, , Italy
A.O.U. Integrata, Verona, , Italy
ASL Viterbo - Ospedale Belcolle, Viterbo, , Italy
Contact Details
Name: Cesare Gridelli, M.D.
Affiliation: S.G.Moscati Hospital
Role: PRINCIPAL_INVESTIGATOR
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