Spots Global Cancer Trial Database for Effect of Metformin on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess
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Trial Identification
Brief Title: Effect of Metformin on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess
Official Title: Effect of Metformin on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess (CBS005)
Study ID: NCT01422746
Interventions
Study Description
Brief Summary: This study will test whether metformin administration can ameliorate androgen (male hormone) overproduction in overweight pubertal girls with androgen excess. The investigators hypothesize that improvement in insulin sensitivity by 12 weeks of metformin administration will improve androgen levels after adrenal stimulation testing with adrenocorticotropic hormone (ACTH) or ovarian stimulation testing with recombinant human chorionic gonadotropin (rhCG).
Detailed Description:
Keywords
Eligibility
Minimum Age: 7 Years
Eligible Ages: CHILD, ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
University of Virginia Center for Research in Reproduction, Charlottesville, Virginia, United States
Contact Details
Name: Christine Burt Solorzano, MD
Affiliation: University of Virginia
Role: PRINCIPAL_INVESTIGATOR
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