Spots Global Cancer Trial Database for Organoids in Predicting Chemoradiation Sensitivity on Rectal Cancer
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Trial Identification
Brief Title: Organoids in Predicting Chemoradiation Sensitivity on Rectal Cancer
Official Title: Validation of Organoids Potential Use as a Companion Diagnostic in Predicting Neoadjuvant Chemoradiation Sensitivity in Locally Advanced Rectal Cancer
Study ID: NCT03577808
Interventions
Study Description
Brief Summary: Patients with locally advanced rectal cancer will receive biopsy before the standard treatment of neoadjuvant chemoradiation. The investigators are going to establish organoids model from the pre-treatment biopsies and expose organoids to irradiation and the same chemotherapy drugs. The sensitivity of irradiation and chemotherapy drugs will be tested in the organoids model. Here, the investigators will launch the observational clinical trial to validate whether the organoids could predict the clinical outcome in locally advanced rectal cancer patients underwent neoadjuvant chemoradiation.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Fudan University, Shanghai, , China
Contact Details
Name: Zhen Zhang, MD
Affiliation: Fudan University
Role: PRINCIPAL_INVESTIGATOR
Name: Guoqiang Hua, PhD
Affiliation: Institute of Radiation Medicine, Fudan University
Role: PRINCIPAL_INVESTIGATOR
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