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Brief Title: A Clinical Study of TJ004309 With Atezolizumab (TECENTRIQ®) in Patients With Ovarian Cancer and Selected Solid Tumors
Official Title: A Phase 2 Clinical Study of TJ004309 in Combination With Atezolizumab (TECENTRIQ®) in Patients With Advanced or Metastatic Ovarian Cancers and Selected Advanced Solid Tumors
Study ID: NCT05001347
Brief Summary: This is a multicenter, open label, Phase 2 study of TJ004309 in combination with atezolizumab in patients with advanced or metastatic solid tumors.
Detailed Description: This is a multicenter, open label, Phase 2 study of TJ004309 in combination with atezolizumab in patients with advanced or metastatic solid tumors. This clinical study includes two cohorts: Cohort 1 will include Immuno-Oncology (IO) treatment naïve ovarian cancer (OC) patients who have progressed on or after platinum therapy; and Cohort 2 will include patients with head and neck squamous cell carcinoma (HNSCC), non-small cell lung cancer (NSCLC), gastrointestinal cancer (GC), triple negative breast cancer (TNBC), or ovarian carcinoma (OC) with PD-L1 expression ≥ 1%. Additional cohorts for selected tumor types might be added later.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Arizona Oncology Associates, Tucson, Arizona, United States
Innovative Clinical Research Institute, Whittier, California, United States
Medical Oncology Hematology Consultants, PA, Newark, Delaware, United States
Illinois Cancer Specialists, Arlington Heights, Illinois, United States
Women's Cancer Care, Covington, Louisiana, United States
Maryland Oncology Hematology, Rockville, Maryland, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York, United States
Duke Cancer Center, Durham, North Carolina, United States
Tri County Hematology and Oncology Associates, Massillon, Ohio, United States
Texas Oncology - Arlington North, Arlington, Texas, United States
Texas Oncology - Austin Central, Austin, Texas, United States
Texas Oncology - Bedford, Bedford, Texas, United States
Texas Oncology - Forth Worth Cancer Center, Fort Worth, Texas, United States
Texas Oncology - The Woodlands, Gynecologic Oncology, The Woodlands, Texas, United States
Texas Oncology - Longview Cancer Center, Tyler, Texas, United States
Virginia Cancer Specialists, Fairfax, Virginia, United States
Northwest Cancer Specialists, Vancouver, Washington, United States