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Spots Global Cancer Trial Database for A Study of PF-07260437 in Advanced or Metastatic Solid Tumors

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Trial Identification

Brief Title: A Study of PF-07260437 in Advanced or Metastatic Solid Tumors

Official Title: A PHASE 1 DOSE ESCALATION AND EXPANSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETIC, PHARMACODYNAMIC, AND ANTITUMOR ACTIVITY OF PF-07260437 IN ADVANCED OR METASTATIC SOLID TUMORS

Study ID: NCT05067972

Study Description

Brief Summary: A study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of PF-07260437, a B7-H4 x CD3 bispecific mAb, in participants aged ≥18 years of age with advanced or metastatic breast cancer, ovarian cancer or endometrial cancer. Adult participants with other advanced or metastatic high B7-H4 expressing tumors may be considered after discussion with and approval from sponsor.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte, California, United States

Moffitt Cancer Center at McKinley Campus, Tampa, Florida, United States

Moffitt Cancer Center, Tampa, Florida, United States

University of Chicago Medical Center, Chicago, Illinois, United States

University of Chicago Comprehensive Cancer Center at Silver Cross Hospital, New Lenox, Illinois, United States

The University of Chicago Medicine Center of Advanced Care Orland Park, Orland Park, Illinois, United States

Montefiore Einstein Center for Cancer Care, Bronx, New York, United States

NEXT Oncology, San Antonio, Texas, United States

Swedish Cancer Institute Edmonds Campus, Edmonds, Washington, United States

Swedish Cancer Institute, Seattle, Washington, United States

Fred Hutchinson Cancer Center, Seattle, Washington, United States

University of Washington Medical Center - Mountlake, Seattle, Washington, United States

Pan American Center for Oncology Trials, LLC, Rio Piedras, , Puerto Rico

Pan American Center for Oncology Trials- Hospital Oncologico, Rio Piedras, , Puerto Rico

Pan American Center for Oncology Trials, Rio Piedras, , Puerto Rico

Contact Details

Name: Pfizer CT.gov Call Center

Affiliation: Pfizer

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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