Spots Global Cancer Trial Database for A Study of PF-07260437 in Advanced or Metastatic Solid Tumors
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Trial Identification
Brief Title: A Study of PF-07260437 in Advanced or Metastatic Solid Tumors
Official Title: A PHASE 1 DOSE ESCALATION AND EXPANSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETIC, PHARMACODYNAMIC, AND ANTITUMOR ACTIVITY OF PF-07260437 IN ADVANCED OR METASTATIC SOLID TUMORS
Study ID: NCT05067972
Study Description
Brief Summary: A study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of PF-07260437, a B7-H4 x CD3 bispecific mAb, in participants aged ≥18 years of age with advanced or metastatic breast cancer, ovarian cancer or endometrial cancer. Adult participants with other advanced or metastatic high B7-H4 expressing tumors may be considered after discussion with and approval from sponsor.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte, California, United States
Moffitt Cancer Center at McKinley Campus, Tampa, Florida, United States
Moffitt Cancer Center, Tampa, Florida, United States
University of Chicago Medical Center, Chicago, Illinois, United States
University of Chicago Comprehensive Cancer Center at Silver Cross Hospital, New Lenox, Illinois, United States
The University of Chicago Medicine Center of Advanced Care Orland Park, Orland Park, Illinois, United States
Montefiore Einstein Center for Cancer Care, Bronx, New York, United States
NEXT Oncology, San Antonio, Texas, United States
Swedish Cancer Institute Edmonds Campus, Edmonds, Washington, United States
Swedish Cancer Institute, Seattle, Washington, United States
Fred Hutchinson Cancer Center, Seattle, Washington, United States
University of Washington Medical Center - Mountlake, Seattle, Washington, United States
Pan American Center for Oncology Trials, LLC, Rio Piedras, , Puerto Rico
Pan American Center for Oncology Trials- Hospital Oncologico, Rio Piedras, , Puerto Rico
Pan American Center for Oncology Trials, Rio Piedras, , Puerto Rico
Contact Details
Name: Pfizer CT.gov Call Center
Affiliation: Pfizer
Role: STUDY_DIRECTOR
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